Prevymis letermovir 240 mg price

Generic Name: letermovir tablets

Brand Name: Prevymis

Drug Class: Antivirals, CMV

What is Prevymis?

Prevymis is a prescription antiviral medicine used to help prevent cytomegalovirus (CMV) infection and disease in people who have received a stem cell transplant or a kidney transplant and who have a high risk for getting CMV disease.

CMV is a common virus that rarely causes problems in healthy people but can cause serious illness or even death in people with weakened immune systems, and especially those who have received an organ transplant or a stem cell transplant.

Prevymis is an antiviral medicine that works to prevent CMV infection and disease by inhibiting viral replication.

Prevymis is taken as an oral tablet once a day or is given by your doctor as an injection through an IV line (intravenously) once a day if you are unable to take the tablets.

What is Prevymis used for?

Prevymis is used to prevent CMV infection and disease in adults who have received an allogeneic hematopoietic stem cell transplant and who are CMV seropositive.

An allogeneic hematopoietic stem cell transplant is a procedure in which a patient receives healthy blood-forming cells (stem cells) from a donor.  A CMV seropositive person has CMV virus in their blood but may not show any symptoms of infection. They are at risk of “reactivation” of the virus if the immune system becomes weakened.

Prevymis is also use to prevent CMV infection and disease in adults who have received a kidney transplant if they are CMV seronegative but have received the kidney from a CMV seropositive donor.

Dosing information

Usual Adult Dose for CMV Prophylaxis:

480 mg orally or by IV infusion once a day

Co-administration with Cyclosporine: 240 mg orally or IV infusion once a day

Duration of therapy:
Allogeneic Hematopoietic Stem Cell Transplant (HSCT): through Day 100 post-transplantation
Kidney Transplant: through Day 200 post-transplantation

Comments:
-Oral and IV doses may be use interchangeably; patients should be switch to oral therapy as soon as possible due to the presence of hydroxypropyl betadex in the IV formulation. IV infusions are administer over 1 hour.
-During clinical trials, the median time to engraftment (defined as absolute neutrophil count of 500/mm³ or greater on 3 consecutive days after transplantation) was 19 days in letermovir-treated patients.
-Potentially significant drug interactions resulting in adverse reactions or reduced therapeutic effect of this drug or the concomitant drug are possible, therefore, consider drug interactions when initiating or completing therapy.

Uses:
– Prophylaxis of cytomegalovirus (CMV) infection and disease in adult CMV-seropositive recipients [R+] of an allogeneic hematopoietic stem cell transplant (HSCT).
– Prophylaxis of CMV disease in adult kidney transplant recipients at high risk (Donor CMV seropositive/Recipient CMV seronegative [D+/R-]).

Important Safety Information

Warnings

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact with letermovir, and some drugs should not be use together.

Before taking this medicine

Some medicines can cause unwanted or dangerous effects when used with Prevymis. Your doctor may need to change your treatment plan if you use any of the following drugs:

• Pimozide
• Cholesterol medication – Pitavastatin, Simvastatin; or
• Ergot medicine – Dihydroergotamine, Ergotamine, Ergonovine, Methylergonovine.

To make sure Prevymis is safe for you, tell your doctor if you have ever had:

• Kidney Disease;
• Liver disease
• Diabetes; or
• High cholesterol or Triglycerides (a type of fat in the blood).

It is not know whether Prevymis will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

What other drugs will affect Prevymis?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your current medicines and any you start or stop using. If you also use cyclosporine, your Prevymis dose will need to be adjust.

Other drugs may interact with letermovir, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Use In Patients With Renal Impairment

• For patients with creatinine clearance (CLcr) greater than 10 mL/min, no dosage adjustment of PREVYMIS is required based on renal impairment [see Use In Specific Populations and CLINICAL PHARMACOLOGY].
• There are insufficient data in patients with CLcr 10 mL/min or less or in patients on dialysis to make PREVYMIS dosing recommendations.
• In patients with CLcr less than 50 mL/min receiving PREVYMIS letermovir price injection, accumulation of the intravenous vehicle, hydroxypropyl betadex, may occur. Closely monitor serum creatinine levels in these patients.

Use In Patients With Hepatic Impairment

No dosage adjustment of Prevymis letermovir price is required for patients with mild (Child-Pugh Class A) or moderate (Child-Pugh Class B) hepatic impairment. Prevymis is not recommended for patients with severe (Child- Pugh Class C) hepatic impairment [see Use In Specific Populations].

Preparation And Administration Of Intravenous Solution

Prevymis injection letermovir price is supplied in 30 mL single-dose vials containing either 240 mg/12 mL per vial (20 mg/mL) or 480 mg/24 mL per vial (20 mg/mL). The preparation and administration instructions are the same for either dose.

Prevymis vials are for single use only. Discard any unused portion.

Preparation And Administration Instructions

IV Bags Materials

Polyvinyl chloride (PVC), ethylene vinyl acetate (EVA) and polyolefin (polypropylene and polyethylene)

Infusion Sets Materials

PVC, polyethylene (PE), polybutadiene (PBD), silicone rubber (SR), styrene–butadiene copolymer (SBC), styrene-butadiene-styrene copolymer (SBS), polystyrene (PS)

Plasticizers

Prevymis letermovir 240 mg Tris (2-ethylhexyl) Trimellitate (TOTM), benzyl butyl phthalate (BBP)

Catheters

Radiopaque Polyurethane

• Prevymis letermovir price 240 mg must be diluted prior to intravenous (IV) use.
• Inspect vial contents for discoloration and particulate matter prior to dilution. Prevymis 240 mg injection is a clear colorless solution and may contain a few product-related small translucent or white particles.
• Do not use the vial if the solution is cloudy, discolored, or contains matter other than a few small translucent or white particles.
• Do not use Prevymis letermovir 240 mg injection with IV bags and infusion set materials containing the plasticizer Diethylhexyl phthalate (DEHP). Use only with IV bags and infusion set materials that are DEHP-free.
• Materials that are phthalate-free are also DEHP-free.
• Do not shake PREVYMIS vial.
• Add one single-dose vial of PREVYMIS injection into a 250 mL pre-filled IV bag containing either 0.9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP and mix bag gently. Do not shake. Only 0.9% Sodium Chloride and 5% Dextrose are chemically and physically compatible with PREVYMIS injection.
• Use compatible IV bags and infusion set materials. Prevymis letermovir 240 mg injection is compatible with the following IV bags letermovir price and infusion set materials. PREVYMIS injection is not recommended with any IV bags or Prevymis 240 mg infusion set materials not listed below Similarly Prevymis price (note that PREVYMIS injection is not recommended for use with polyurethane-containing IV administration set tubing).

FAQ

What is Prevymis used for?

PREVYMIS is a prescription drug to help prevent cytomegalovirus (CMV) infection and disease in adults who have received an allogeneic hematopoietic (bone marrow) stem cell transplant and are at high risk for CMV infection and disease.

Is Prevymis an antiviral?

Prevymis is an antiviral drug used to prevent infections caused by cytomegalovirus (CMV) in adults who have undergone allogeneic hematopoietic stem cell transplantation.

What class of drug is Prevymis?

Letermovir belongs to a group of drugs called antivirals. It is used to prevent infection caused by cytomegalovirus (CMV) in adults who have had stem cell transplants and cells from another person and who are at risk of developing CMV disease.

What are the side effects of Prevymis?

Do not start or stop taking any other medication without first talking to your healthcare professional. Common side effects of PREVYMIS include nausea, diarrhea, vomiting, swelling of the arms and legs, cough, headache, fatigue, and stomach (abdominal) pain. These are not possible side effects of Prevymis.

How long to take letermovir?

For the dosage (tablets): For the prevention of CMV infection or disease in patients who have received a hematopoietic stem cell transplant: Adults: 480 milligrams (mg) once daily, starting between day 0 and day 28, and -continue to date. 100 later. transplantation. Children: Use and dose should be determined by your doctor.

Polyurethane

• Firstly Once diluted, the solution of Prevymis 240 mg is clear, and ranges from colorless to yellow. Variations of color within this range do not affect the quality of the product.
• Secondly Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration.
• Thirdly Discard if the diluted solution is cloudy, Prevymis 240 mg discolored, or contains matter other than a few small translucent or white particles.
• The diluted solution is stable for up to 24 hours at room temperature or up to 48 hours under refrigeration at 2°C to 8°C (36°F to 46°F) Prevymis 240 mg price (this time includes storage of the diluted solution in the intravenous bag through the duration of infusion).
• The diluted solution must administer through a sterile Prevymis 240 mg price 0.2 micron or 0.22-micron Polyether sulfone (PES) in-line filter.
• Do not administer through a filter other than a sterile 0.2 micron or 0.22 micron PES in-line filter.
• Administer the entire contents of the intravenous bag letermovir price by Intravenous Infusion via a peripheral catheter or central venous line at a constant rate over 1 hour [see Important Dosing And Administration Information].

Compatible Drug Products Used For Intravenous Administration

Compatible Drug Products

The physical Compatibility of Prevymis Injection with select Injectable drug Prevymis Letermovir price products was Evaluate in two commonly available Diluents. So, Prevymis should not Co-Administered through the same Intravenous line (or cannula) with other drug products and diluent Combinations except those listed below. Refer to the Respective Prescribing information of the Co-Administered drug(s) to confirm Compatibility of Simultaneous Co-Administration.