Brukinsa is used to treat adults with mantle cell lymphoma, Waldenström’s macroglobulinemia, marginal zone lymphoma, chronic lymphocytic leukemia, small lymphocytic lymphoma, and follicular lymphoma. Brukinsa Zanubrutinib 80 mg is an oral capsule or tablet that is taken once or twice a day. Also Brukinsa Zanubrutinib 80 mg price in india best online at Yourmedikart
Pronunciation: brew-KIN-za
Generic name: zanubrutinib
Dosage form: oral capsule (80 mg), oral tablet (160 mg [scored])
Drug class: BTK inhibitors
What is Brukinsa used for?
Brukinsa (zanubrutinib) is commonly used for the following conditions.
- Mantle cell lymphoma, which is a type of cancer that affects your white blood cells
- Waldenstrom’s macroglobulinemia, which is a type of cancer that affects your white blood cells
- Marginal zone lymphoma, a type of non-Hodgkin lymphoma cancer that affects your white blood cells
- Chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), a type of cancer that affects your white blood cells
- Follicular lymphoma, a type of cancer that affects your white blood cells
Learn more about Treating Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma With Brukinsa.
Brukinsa may also be used for other conditions as determined by your healthcare provider.
How should I take Brukinsa?
Take exactly as directed by your healthcare provider.
- Take the capsules/tablets once or twice daily as directed.
- Swallowed the capsules whole with a full glass of water. Do not open, break, or chew the capsules.
- The tablets can be split in half down the score line as prescribed by your healthcare provider. Do not chew or crush the tablets.
- May be taken with or without food.
- The dosage may need to be reduced in those with severe liver disease.
- Take until disease progression or unacceptable toxicity occurs.
What are the most common side effects of Brukinsa?
The most common side effects of Brukinsa are listed below. Tell your healthcare provider if you have any of these side effects that bother you.
- Blood disorders (see below)
- Infection in the nose or throat, sore throat, or common cold symptoms
- Bleeding
- Muscle or joint pain
There may be other side effects of Brukinsa that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at or by calling 800-FDA-one088. In Canada, you can report side effects to Health Canada at or by calling 866-two34-two345.
Before taking
Before you start treatment with Brukinsa, tell your healthcare provider about all of your medical conditions, including if you:
- Have bleeding problems
- Have had recent surgery or plan to have surgery. Your healthcare provider may stop Brukinsa for any planned medical, surgical, or dental procedure
- Have an infection
- Have or had heart rhythm problems
- Have high blood pressure
- Have liver problems, including a history of hepatitis B virus (HBV) infection
- Take any other medicines, including prescription and over-the-counter medicines, vitamins, and herbal supplements
- Are pregnant or plan to become pregnant
- Are breastfeeding or plan to breastfeed.
Pregnancy
Brukinsa can harm your unborn baby. If you can become pregnant, your healthcare provider may do a pregnancy test before starting treatment with this medicine.
You may need to have a negative pregnancy test before you start using Brukinsa. Females should not become pregnant during treatment and for at least 1 week after the last dose. You should use effective birth control (contraception) during treatment and for at least 1 week after the last dose.
Males should avoid getting female partners pregnant during treatment and for at least 1 week after the last dose of Brukinsa. You should use effective birth control (contraception) during treatment and for at least 1 week after the last dose.
Breastfeeding
It is not known if Brukinsa passes into your breast milk. Do not breastfeed during treatment and for at least 2 weeks after your last dose.
What are the serious side effects of Brukinsa?
While less common, the most serious side effects of Brukinsa are described below, along with what to do if they happen.
Severe Allergic Reactions. Brukinsa may cause allergic reactions, which can be serious. Stop taking Brukinsa and get help right away if you have any of the following symptoms of a serious allergic reaction.
- Breathing problems or wheezing
- Racing heart
- Fever or general ill feeling
- Swollen lymph nodes
- Swelling of the face, lips, mouth, tongue, or throat
- Trouble swallowing or throat tightness
- Itching, skin rash, or pale red bumps on the skin called hives
- Nausea or vomiting
- Dizziness, feeling lightheaded, or fainting
- Stomach cramps
- Joint pain
Bleeding
Brukinsa can increase your risk of bleeding that may be dangerous and life-threatening. Call your healthcare provider right away if you have any of the following symptoms of bleeding.
- Black or tarry-looking stools
- Pink or brown urine
- Unexpected or unexpected bleeding
- Vomit that looks like coffee grounds
- Coughing up blood
- Bruising
- Dizziness, weakness, confusion
- Change in speech
- Headache that lasts a long time
Infection
Brukinsa can increase the risk of infections, including serious infections that can be life-threatening. Call your healthcare provider right away if you have an infection or any of the following symptoms.
- Burning or stinging when you pee
- Cough or coughing up blood
- Fever, sweats, chills, or muscle aches
- Shortness of breath
- Diarrhea or stomach pain
- Weight loss
Blood Disorders
Brukinsa can cause changes in your blood tests including low platelet levels (thrombocytopenia), low neutrophil levels (neutropenia), and low red blood cell levels (anemia). Keep all appointments with your healthcare provider to have your blood checked. Stop using Brukinsa and get help right away if you have any of the following symptoms of blood disorders.
- Fever
- Shortness of breath
- Pale or yellowish skin
- Easy bruising or bleeding
- Frequent infection
- Unusual weakness or tiredness
- Dizziness, lightheadedness, or feeling like you are about to pass out
- Headache
- Fast or abnormal heartbeat
Cancer
Brukinsa can cause a new cancer to develop, including cancers of the skin or other organs. Tell your healthcare provider about any new symptoms that you may get. Use sun protection when exposed to the sun.
Heart Rhythm Changes
Brukinsa may cause heart rhythm problems including atrial flutter, atrial fibrillation, and ventricular arrhythmia. Call your healthcare provider right away if you have any of the following symptoms.
- Fast, irregular, or skipping heartbeats
- Dizziness
- Fainting
- Shortness of breath
- Chest discomfort
Liver Damage
Liver damage, also called hepatotoxicity, can happen when taking Brukinsa. Keep all appointments with your healthcare provider to have your blood checked. Your healthcare provider may monitor your liver function before and while taking Brukinsa. Call your healthcare provider right away if you have any of the following symptoms of liver damage.
- Nausea or vomiting
- Stomach or belly pain
- Fever
- Weakness or unusual tiredness
- Itching
- Loss of appetite
- Light-colored poop
- Dark-colored urine (pee)
- Your skin or the whites of your eyes turning yellowish in color (also called jaundice)
Warnings & Precautions
Who should not use Brukinsa?
Allergies to Ingredients
People who are allergic to any of the following should not take Brukinsa.
- Brukinsa
- Zanubrutinib
- Any of the ingredients in the specific product dispensed
Your pharmacist can tell you all of the ingredients in Brukinsa.
What should I know about Brukinsa before using it?
- Do not chew, cut, or crush Brukinsa. Swallow the capsule whole with water.
- Brukinsa can increase your chances of bleeding. Taking certain medicines with Brukinsa can make this worse. Tell your healthcare provider about all of the medicines you are taking.
- Do not take Brukinsa unless it has been prescribed to you by a healthcare provider. Take it as prescribed.
- Do not share Brukinsa with other people, even if they have the same condition as you. It may harm them.
- Keep Brukinsa out of the reach of children.
What should I tell my healthcare provider before using Brukinsa?
Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Brukinsa is right for you.
In particular, make sure that you discuss any of the following.
Current and Past Health Conditions.
Tell your healthcare provider if you have any of the following.
- History of cancer
- Bleeding problems
- An infection
- Heart problems
- Liver problems, including a history of hepatitis B
Surgery
Tell your healthcare provider if you have had a recent surgery or have any upcoming medical or dental surgeries. Brukinsa can increase your chances of bleeding. Your healthcare provider may temporarily stop Brukinsa depending on the type of surgery you recently received or are planning to receive.
Other Medicines and Supplements.
Brukinsa may interact with other medicines and supplements. Before taking Brukinsa, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.
Pregnancy
Brukinsa may cause harm to an unborn baby. Tell your healthcare provider if you are or plan to become pregnant. If you are a woman, it is not recommended to get pregnant while taking Brukinsa and for at least one week after your last dose. It is recommended to use effective contraception (birth control, condoms, etc.) while taking Brukinsa and for at least one week after your last dose. If you are a man, it is not recommended to get your female partner pregnant while taking Brukinsa and for at least one week after your last dose.
Breastfeeding
It is not known if Brukinsa passes into breast milk. It is not recommended to take Brukinsa while you are breastfeeding and for at least two weeks after your last dose. Tell your healthcare provider if you are breastfeeding or plan to breastfeed.
How can I get more information about Brukinsa?
For more information about Brukinsa, you can visit the manufacturer’s website at www.brukinsa.com or call them at 833-two34-4363.
Interactions
Does Brukinsa interact with foods or drinks?
There are no known interactions between Brukinsa and foods or drinks.
It is unknown if drinking alcohol will affect Brukinsa, but both Brukinsa and alcohol can increase your risk of bleeding. It is best to limit the amount of alcohol you drink.
Does Brukinsa interact with other medicines (drug interactions)?
In particular, make sure that you discuss if you are using any of the following before taking Brukinsa.
- Clarithromycin, which is a medicine used for bacterial infections
- Posaconazole, which is a medicine used for fungal infections
Many other medicines may alter the blood levels of Brukinsa. Tell your healthcare provider about all medicines that you take or have recently taken.
This may not be a complete list of medicines that can interact with Brukinsa. Always check with your healthcare provider.
