Trodelvy 180 Mg

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Trodelvy 180 Mg Per Vial

Generic Name : Sacituzumab Govitecan Hziy

Trodelvy

What is Trodelvy Used For and Trodelvy Price

Trodelvy (Generic Name: sacituzumab govitecan-hziy) is supported to treat grown-ups diagnosed to have unresectable privately progressed or metastatic triple-negative breast cancer who have received at least two or more systemic therapies, at least one of which was for advanced-stage disease. Trodelvy price in India is low.

Progressed stage breast cancer includes privately progressed breast cancer and metastatic breast disease. Privately progressed breast cancer is breast cancer that has spread to tissue near the breast. Unresectable methods the cancer can’t be taken out with a medical procedure. Metastatic breast cancer is breast cancer that has spread to parts of the body away from the breast, like the bones or liver. Systemic treatments will be therapies that include the whole body, not simply the region where the cancer was. Chemotherapy and focused on treatments are systemic treatments.

Triple-negative breast cancer is disease that has no receptors for the hormones estrogen and progesterone, just as no receptors for the HER2 protein. This restricts the medications that can be used to treat the cancer.

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Indications

TRODELVY is suitable for the treatment of unresectable locally advanced or metastatic triple-negative breast cancer (mTNBC) adult patients who have previously received two or more systemic treatments, at least one of which is used for metastatic disease.

Most Important Safety Information

Low white platelet count (neutropenia) which is normal and can once in a while be extreme and lead to diseases that can be dangerous or cause death. Your healthcare provider should check your platelet counts during therapy. If your white platelet check is too low, your healthcare provider may have to bring down your dose, give you a medication to help prevent low platelet count with future dosages of TRODELVY, or now and again may stop TRODELVY. Your healthcare provider may have to give you anti-microbial prescriptions if you develop fever while your white platelet count is low. Call your healthcare provider right away if you develop any of the following signs of infection: fever, chills, cough, shortness of breath, or burning or pain when you urinate.

Severe diarrhea. Diarrhea is normal and can be extreme. Your doctor should monitor you for diarrhea and give you medication on a case by case basis to help control it. If you lose an excess of body liquid (drying out), your doctor may have to give you liquids and electrolytes to supplant body salts. If diarrhea happens later in your treatment, your doctor may check you to check whether it very well might be brought about by a disease. Your doctor may diminish your dose or stop TRODELVY if your diarrhea is serious and can’t be controlled with against diarrheal drugs.

Call your doctor right the first occasion when that you get diarrhea during treatment with TRODELVY; if you have black or bloody stools; if you have symptoms of dehydration, like lightheadedness, dizziness, or faintness; if you can’t take liquids by mouth because of nausea or vomiting; or if you can’t get your the diarrhea under control within 24 hours.

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Do not receive Trodelvy if you have had a severe allergic reaction

Nausea and vomiting are common with TRODELVY and can sometimes be severe. Before each dose of TRODELVY, you will receive medicines to help prevent nausea and vomiting along with medicines to take home with instructions about how to take them. Call your healthcare provider right away if you have nausea or vomiting that is not controlled with the medicines prescribed for you. Your healthcare provider may decide to decrease your dose or stop TRODELVY if your nausea and vomiting is severe and cannot be controlled with anti-nausea medicines.

Allergic reactions which can be serious and life-threatening. Tell your healthcare provider or nurse right away if you get any of the following symptoms during your infusion of TRODELVY or within 24 hours after: swelling of your face, lips, tongue, or throat; hives; skin rash, itching, or flushing of your skin; fever; difficulty breathing or wheezing; lightheadedness, dizziness, feeling faint, or pass out; or chills or shaking chills (rigors).

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trodelvy 180 mg

Before taking Trodelvy, tell your doctor about all of your medical conditions

  • Tell your doctor right away if you or your partner become pregnant during treatment with TRODELVY.
  • having liver problems.
  • are pregnant or plan to become pregnant. TRODELVY can harm your unborn baby. Your healthcare provider should check to see if you are pregnant before you start receiving TRODELVY. TRODELVY may cause fertility problems in females, which could affect your ability to have a baby. Talk to your healthcare provider if fertility is a concern for you.
  • Males with a female partner who can become pregnant should use effective birth control during treatment and for 3 months after your last dose of TRODELVY.
  • Females who can become pregnant should use effective birth control during treatment and for 6 months after your last dose of TRODELVY. Talk to your healthcare provider about birth control choices that may be right for you during this time.

Side Effects

Most common side effects:

  • feeling tired or weak
  • hair loss
  • decreased red blood cell count
  • constipation
  • decreased appetite
  • rash
  • and stomach-area (abdominal) pain
  • discomfort

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Important Safety Information

TRODELVY can cause serious side effects, including low white blood cell count and diarrhea:

Warnings and Precautions

Do not substitute Trodelvy or use it with other drugs containing irinotecan or its active metabolite SN 38. The risk of severe neutropenia. If the ANC is <1500/mm3 on the 1st day of any cycle, the neutrophil count is <1000/mm3 on the 8th day of any cycle, or if neutropenia occurs, stop treatment. Monitor CBC regularly during treatment. Consider G-CSF for secondary prevention. If febrile neutropenia occurs, start anti-infective treatment immediately. Risk of severe diarrhea (if it occurs, monitor and evaluate the cause of infection), nausea, and vomiting. The withholding dose is used for grade 3/4 diarrhea, grade 3 nausea, and grade 3/4 vomiting; recovery when resolved to ≤ grade 1; loperamide, additional antiemetics, and other supportive measures are given according to clinical indications. Closely monitor hypersensitivity reactions and infusion-related reactions during each infusion and at least 30 minutes after the infusion. If a life-threatening infusion-related reaction occurs, the drug is permanently discontinued. Patients who are homozygous for the UGT1A1*28 allele are closely monitored for adverse reactions of reduced UGT1A1 activity; permanent retention or suspension according to the severity of the reaction. Moderate to severe liver failure. Embryo-fetal toxicity. It is recommended to use effective contraceptive methods during 6 months (female) or 3 months (male and female). Female partner) after the last dose. Pregnancy: rule out the state before the onset. Nursing mothers: Not recommended (during the last dose and within 1 month after it).

FAQ

What is TRODELVY used for?

TRODELVY is a drug used to treat adult patients with triple-negative breast cancer that has spread to other parts of the body (metastatic). It should be used in patients with metastatic disease that have received at least two previous treatments.

How long do you take TRODELVY?

You will receive TRODELVY as an IV infusion from your doctor. Each treatment cycle is 21 days. The drug is given once a week for 2 weeks, and then the drug is stopped for 1 week.

Is TRODELVY a chemo?

Trodelvy (sacituzumab govitecan-hziy) is a targeted therapy called an antibody-drug conjugate. It works by delivering chemotherapy drugs directly to cancer cells to prevent their growth and spread.

Is TRODELVY a pill?

What is Trodelvy and what is its purpose? Trodelvy is a prescription drug used to treat adult breast cancer: estrogen receptor (HR) negative and human epidermal growth factor receptor 2 (HER2) negative (also known as human epidermal growth factor (HER2) cancer). Triple negative breast cancer), and.

How effective is Trodelvy?

In the first study, Trodelvy was well tolerated and produced an overall response rate of 30% in patients who failed an average of 5 previous treatments. In addition, 45% of patients were in stable condition, and 16% had a response that lasted more than 6 months.

 

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