Nucala 100 Mg/Vial Nucala 100 mg manufactured by GSK | Used to treat severe eosinophilic asthma or to treat eosinophilic granulomatosis with polyangiitis (EGPA). Nucala mepolizumab 100 mg manufactured by GSK | Nucala injection cost and Price Best at Yourmedikart. Used to treat severe eosinophilic asthma.

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GSK

Generic Name : Mepolizumab

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NUCALA is a medication which contains the active Substance Mepolizumab, a Monoclonal Antibody. However, This Antibody blocks a Particular protein called Interleukin-5. By blocking the activity of interleukin 5, NUCALA limits the production of more eosinophils (a kind of white platelet) from the bone marrow and brings down the quantity of eosinophils in the Bloodstream and the lungs. Nucala 100 mg price in india is low. Cost of Mepolizumab is low at yourmedikart

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NUCALA is use to treat severe Eosinophilic Asthma or to treat Eosinophilic Granulomatosis with Polyangiitis (EGPA).

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Severe eosinophilic asthma

Some people with severe asthma have an excessive number of eosinophils (a type of white platelet) in the blood, lungs and tissues. Having such a large number of eosinophils in your blood can harm the airways and can make your asthma to get worse or can expand the quantity of your asthma flare ups.

NUCALA is used to treat asthma by diminishing the frequency of asthma flare ups in adolescents (more than 12 years old) and adults who are now accepting asthma medicines, but whose asthma flare ups are not very much controlled by medicines, for example, high-dose corticosteroid inhalers or beta-agonist inhalers.

NUCALA can also be used to help diminish the everyday dose of oral corticosteroids in patients taking these prescriptions to control asthma symptoms and flare ups.

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Eosinophilic Granulomatosis with Polyangiitis (EGPA)

• EGPA is a condition where people have such a large number of eosinophils in the blood and tissues, and furthermore have inflammation of the veins (vasculitis). EGPA most usually affects the lungs and sinuses however regularly affects different organs including the skin, heart, kidneys, nerves or bowels.
• NUCALA can decrease symptoms and delay a flare-up of these indications in people who are now taking corticosteroids.
• NUCALA can also help lessen the day-by-day dose of corticosteroids you need to control your side effects.
• Ask your doctor if you have any questions about why this medicine has been prescribed for you.
• This medication is available just with a doctor’s prescription.
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Description

Mepolizumab is a humanized IL-5 antagonist Monoclonal antibody. Mepolizumab is produce in Chinese Hamster ovary cells through Recombinant DNA Technology. The molecular weight of mepolizumab is approximately 149 kDa.

NUCALA is provide as a sterile, white to off-white, freeze-dry powder without preservatives, and is use for subcutaneous injection after reconstitution. Use 1.2 ml of sterile water for injection, USP after reconstitution, the resulting Concentration is 100 mg/ml, and 1 ml is obtain. Each single dose Nucala injection cost vial releases 100 mg of Mepolizumab, Polysorbate 80 (0.67 mg), sodium Hydrogen Phosphate Heptahydrate (7.14 mg) and sucrose (160 mg), with a pH of 7.0.

How to use Nucala 100 Mg

NUCALA is give by injection under your skin (subcutaneous injection).

This is a solution for infusion in pre-filled pen (auto-injector) which can be give either by you, your guardian or a doctor/nurse.

Your doctor or nurse will choose if you or your parental figure can inject Nucala manufacturer. If they consider self -administration appropriate, your doctor or medical caretaker will provide training to show you or your parental figure the right method to use NUCALA.

Thirdly You can inject NUCALA under your skin in either your stomach area (abdomen) or upper leg (thigh). Your parental figure can inject NUCALA at these sites or into your upper arm. You should not give injections into areas where the skin is tender, bruised, red, or hard.

Like all prescriptions, NUCALA can cause side effects, although not every person gets them. The side effects brought about by NUCALA are usually mild to moderate but can occasionally be serious.

Try not to be frighten by the following list of side effects. You may not experience any of them.

Ask your doctor or drug specialist to answer any inquiries you may have.

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Very common side effects

This may affect more than 1 out of 10 people:

• Headache

Common side effects

These may affect up to 1 in 10 people:

• Urinary tract infection (blood in urine, painful and frequent urination, fever, pain in lower back)
• Lower respiratory tract infection
• Eczema
• Fever
• Headache, injection site reactions, diarrhea and vomiting.
• Nasal congestion
• Injection-site reaction (pain, redness, swelling, itching, and burning sensation of the skin near where the injection was give)
• Pharyngitis (sore throat)
• Back pain

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Dosage and Administration

NUCALA is for subcutaneous use only in adults and adolescents Nucala injection cost with severe asthma 12 years and older. Most Importantly The recommended dose of NUCALA for adults and adolescents 12 years and older is 100 mg, once every 4 weeks, by subcutaneous injection in the upper arm, thigh, Nucala price or abdomen [see for Preparation and administration of NUCALA for injection vials and preparation and administration of NUCALA injection pre-filled auto-injector and pre-filled syringe]. And specifically, The recommended dose of NUCALA injection for children 6 to 11 years old for children 6 to 11 years old is 40 mg once every 4 years. Inject subcutaneously in the upper arm, thigh or abdomen for several weeks.

Secondly The recommended dose of NUCALA for eosinophilic granuloma with polyangiitis is 300 mg, After that subcutaneously injected every 4 weeks, and 100 mg is injected separately into the upper arm, thigh or abdomen in 3 separate doses [see the preparation and administration and preparation of NUCALA in the injection bottle and Administration of NUCALA injection pre-filled auto-injector and pre-filled syringe]. Inject 100 mg separately, at least 5 cm (approximately 2 inches) apart.

Further, The recommended dose for hyper eosinophilic syndrome is 300 mg. Top of the abdomen [see Preparation and administration of NUCALA for injection vials and preparation and administration of pre-filled auto injectors and pre-filled syringes for injection of NUCALA]. Therefore Inject 100 mg separately, at least 5 cm (approximately 2 inches) apart.

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Warnings

Hypersensitivity reactions (eg, Angioedema, Bronchospasm, Hypotension, urticaria, rash) Reported; But those Reactions usually arise inside Nucala price hours of Administration, however in a few times will have a not on time onset (ie, days); stop drug with inside the occasion of an allergy reaction.

Secondly Not for treatment of acute asthma symptoms or acute exacerbations; similarly, do not use to treat acute bronchospasm or status asthmaticus; instruct patients to seek immediate medical advice if their asthma remains uncontrolled or worsens after initiating mepolizumab.

Although in clinical trials, 2 serious adverse reactions of herpes zoster occurred during treatment compared with none in placebo; But consider varicella vaccination if medically appropriate before initiating treatment.

Do not discontinue Systemic or inhale Corticosteroids Abruptly upon initiation mepolizumab. reductions in corticoster dose, if appropriate, should gradual and perform under the direct supervision of a physician. Reduction in Corticosteroid dose may be Associate with Systemic Withdrawal Symptoms and/or Unmask Conditions Previously Suppresses by systemic Corticosteroid therapy.

After all Eosinophils may be involve in the immunological Response to some Helminth Infections. Nucala manufacturer Patients with know Parasitic infections were exclude from participation in clinical trials. treat patients with Preexisting Helminth Infection before Initiating Mepolizumab; Nucala injection cost However, if Helminth Infection occurs while Nucala price Receiving Mepolizumab that does not respond to Treatment, Nucala injection cost Discontinue Mepolizumab until the infection Resolves.

FAQ

What is Nucala use for?

NUCALA is an Alternate kind of treatment for your severe asthma. It's an Injection you get every 4 weeks in your doctor clinic or take at home. When added to your present asthma meds, NUCALA may Diminish airway Inflammation that can cause severe asthma attacks.

How quickly does Nucala work?

Nucala begins working within 48 hours; however, it might require as long as about a month before the maximum effect of Nucala is see for both asthma and Eosinophilic Granulomatosis with Polyangiitis (EGPA).

How long should I take Nucala?

Nucala is give once every four weeks. Xolair might be give once every two weeks or once every four weeks. The dosage depends upon your age, body weight, and IgE level before starting treatment.

Does Nucala lower immune system?

Expanded Infections (infections Identified with Alteration in Immune response) Nucala brings down the body's levels of certain white Platelets, called Eosinophils, and Patients with low white Platelet checks have a higher Possibility of Developing an Infection.

Is Nucala safe?

Nucala In Children The safety and Efficacy of Nucala for severe asthma, and with an Eosinophilic Phenotype, have set up in Pediatric patients Matured 6 years and older. The safety and Efficacy of Nucala in Pediatric patients aged Nucala price younger although than 6 years with severe asthma have not set up.