Cabometyx Cabozantinib 60 mg Tablet price in india best at Yourmedikart and uses treat various types of cancer

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Generic Name : Cabozantinib

What is Cabometyx Used For and Cabometyx Cost

• This medication is used to treat various types of cancer (including kidney, thyroid, liver cancer). Cabozantinib belongs to a class of drugs known as tyrosine kinase inhibitors. It works by slowing or stopping the growth of cancer cells. Cabometyx cost is low in India. Buy Cabozantinib tablets online at lowest price on yourmedikart.store

Description

• CABOMETYX is the (S)-malate of a kinase inhibitor cabozantinib. Carboninib (S)-malate is chemically described as N- (4- (6,7-dimethoxyquinolin-4-yloxy) phenyl) -N’- (4- (Fluorophenyl) cyclopropane-1,1-dimethylamide, (2S)-Hydroxy succinate.
• The molecular formula is C28H24FN3O5·C4H6O5, and the molecular weight of the malate salt is 635.6 Daltons. Cabozantinib (S)-Malate is a white to off-white solid, almost insoluble in aqueous media.
• CABOMETYX (Cabotinib) tablets for oral administration are available as film-coated tablets, containing 20 mg, 40 mg, or 60 mg cabozantinib, which is equivalent to 25 mg, 51 mg, or 76 mg cabozantinib, respectively (S) Malate.
• CABOMETYX also contains the following inactive ingredients: microcrystalline cellulose, anhydrous lactose, hydroxypropyl cellulose, croscarmellose sodium, colloidal silicon dioxide and magnesium stearate. The film coating contains Hypromellose, titanium dioxide, triacetin and yellow iron oxide.
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What is CABOMETYX?

Cabometyx is a cancer medicine used to treat adults with:

• Advanced renal cell carcinoma (a kidney cancer). It is used in patients who have been previously treated with a type of cancer medicine called vascular endothelial growth factor (VEGF) inhibitor. It is also used in patients who have not had previous treatment and whose cancer is at moderate or high risk of rapidly getting worse.
• Hepatocellular carcinoma (a liver cancer). It is used on its own in patients who have already been treated with the cancer medicine sorafenib.
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How does CABOMETYX work?

• All cells have signals that tell the cell when to grow, divide, or die. Unlike normal cells, cancer cells don’t stop growing and dividing when they should. This out-of-control growth can cause tumors to form.
• CABOMETYX is thought to work by helping to block some signals that:

• • Encourage growth of new blood vessels that feed cancer cells
  • Tell cells to grow and divide

• Blocking these actions can lead to cell death. When the cancer cells die, tumors are more likely to stop growing and may even shrink. CABOMETYX may affect both normal and cancer cells.

  CABOMETYX is a prescription medicine used to treat:

       Individuals with kidney malignant growth (renal cell carcinoma). CABOMETYX might be utilized:

• Alone to treat individuals with renal cell carcinoma (RCC) that has spread (progressed RCC)
• In blend with nivolumab when your malignant growth has spread (progressed RCC), and you have not as of now had treatment for your high level RCC
• People with liver cancer (hepatocellular carcinoma) who have been previously treated with the medicine sorafenib.
• It is not known if CABOMETYX is safe and effective in children.
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What are the possible side effects of CABOMETYX?

CABOMETYX may cause serious side effects, including:

• Bleeding (hemorrhage).

• CABOMETYX can cause severe bleeding that may lead to death. Tell your healthcare provider right away if you get any signs of bleeding during treatment with CABOMETYX, including:

• • Coughing up blood or blood clots
  • Vomiting blood or if your vomit looks like coffee grounds
  • Red or black (looks like tar) stools
  • Menstrual bleeding that is heavier than normal
  • Any unusual or heavy bleeding
  • A tear in your stomach or intestinal wall (perforation) or an abnormal connection between 2 parts of your body (fistula). Tell your healthcare provider right away if you get tenderness or pain in your stomach area (abdomen) that is severe or that does not go away.

• Blood clots, stroke, heart attack, and chest pain. Get emergency help right away if you get:

• • Swelling or pain in your arms or legs
  • Shortness of breath
  • Feel lightheaded or faint
  • Sweating more than usual
  • Numbness or weakness of your face, arm or leg, especially on one side of your body
  • Sudden confusion, trouble speaking or understanding
  • Sudden trouble seeing in one or both eyes
  • Sudden trouble walking
  • Dizziness, loss of balance or coordination
  • A sudden severe headache

• High blood pressure (hypertension).

  • Hypertension is common with CABOMETYX and sometimes can be severe. Your healthcare provider will check your blood pressure before starting CABOMETYX and regularly during treatment with CABOMETYX.
  • If needed, your healthcare provider may prescribe medicine to treat your high blood pressure.
  • Tell your healthcare provider if you develop severe headaches, nose bleeds, tiredness or confusion, vision changes, chest pain, trouble breathing, irregular heartbeat, or blood in your urine.
  • Diarrhea is common with CABOMETYX and can be severe. If needed, your healthcare provider may prescribe medicine to treat your diarrhea. Tell your healthcare provider right away if you have frequent loose, watery bowel movements.
  • A skin problem called hand-foot skin reaction. Hand-foot skin reactions are common and can be severe. Tell your healthcare provider right away if you have rashes, redness, pain, swelling, or blisters on the palms of your hands or soles of your feet.

• Liver problems.

  • Liver problems may happen during treatment with CABOMETYX. When CABOMETYX is taken in combination with nivolumab, severe changes in liver function tests may happen more often than if you take CABOMETYX alone. Your healthcare provider will do blood tests to check your liver function before and during treatment with CABOMETYX.
  • Tell your healthcare provider right away if you develop symptoms of liver problems including yellowing of your skin or the whites of your eyes, severe nausea or vomiting, pain on the right side of your stomach area (abdomen), dark urine, bleeding or bruising more easily than normal.

• Adrenal gland problems.

  • Your healthcare provider will monitor you for this problem. Your healthcare provider may prescribe hormone replacement therapy or corticosteroid medicines if needed. Tell your healthcare provider right away if you develop any of the following signs or symptoms: extreme tiredness, dizziness or fainting, weakness, nausea, or vomiting.
  • Protein in your urine and possible kidney problems. Symptoms may include swelling in your hands, arms, legs, or feet. Your healthcare provider will check you for this problem during treatment with CABOMETYX.

• Severe jawbone problems (osteonecrosis).

  • Your healthcare provider should examine your mouth before you start and during treatment with CABOMETYX. Tell your dentist that you are taking CABOMETYX. It is important for you to practice good mouth care during treatment with CABOMETYX.
  • Tell your healthcare provider right away if you develop any symptoms of jaw problems, including jaw pain, toothache, or sores on your gums.

• Wound healing problems.

  • Wound healing problems have happened in some people who take CABOMETYX. Tell your healthcare provider if you plan to have any surgery before or during treatment with CABOMETYX.
  • You should stop taking CABOMETYX at least 3 weeks before planned surgery.
  • Your healthcare provider should tell you when you may start taking CABOMETYX again after surgery.
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• Reversible Posterior Leukoencephalopathy Syndrome (RPLS).

  • A condition called reversible posterior leukoencephalopathy syndrome can happen during treatment with CABOMETYX. Tell your healthcare provider right away if you have headaches, seizures, confusion, changes in vision, or problems thinking.

Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with CABOMETYX if you have certain side effects.

The most common side effects of CABOMETYX include:

• Tiredness
• Decreased appetite
• Nausea
• Vomiting
• Weight loss
• Constipation
• Difficulty speaking

The most common side effects of CABOMETYX when used in combination with nivolumab include:

• Tiredness
• Mouth sores
• Rash
• Low thyroid hormone levels (hypothyroidism)
• Pain in muscles, bones, and joints
• Decreased appetite
• Nausea
• Changes in the way things taste
• Stomach-area (abdominal) pain
• Cough
• Upper respiratory tract infection

Before you take CABOMETYX, tell your healthcare provider about your entire medical conditions, including if you:

• Have had a liver problem other than liver cancer.
• Have a recent history of bleeding, including coughing up or vomiting blood, or black tarry stools.
• Have an open or healing wound.
• Have high blood pressure.

Plan to have any surgery, dental procedure, or have had a recent surgery. You should stop treatment with CABOMETYX at least 3 weeks before planned surgery.

Are pregnant, or plan to become pregnant. CABOMETYX can harm your unborn baby.

• If you are able to become pregnant, your healthcare provider will check your pregnancy status before you start treatment with CABOMETYX.
• Females who are able to become pregnant should use effective birth control (contraception) during treatment and for 4 months after your final dose of CABOMETYX.
• Talk to your healthcare provider about birth control methods that may be right for you.
• If you become pregnant or think you are pregnant, tell your healthcare provider right away.
• Are breastfeeding or plan to breastfeed. It is not known if CABOMETYX passes into your breast milk. Do not breastfeed during treatment and for 4 months after your final dose of CABOMETYX.
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Before you take CABOMETYX

• Have a low calcium level in your blood (hypocalcemia).
• Have a recent history of bleeding, including coughing up or vomiting blood, or black tarry stools.
• Plan to have any surgery, dental procedure, or have had a recent surgery. You should stop treatment with CABOMETYX at least 3 weeks before planned surgery.
• Have high blood pressure.
• Have had a liver problem other than liver cancer.
• Have an open or healing wound.
• Are pregnant, or plan to become pregnant. CABOMETYX can harm your unborn baby.
• Females who are able to become pregnant should use effective birth control (contraception) during treatment and for 4 months after your final dose of CABOMETYX.
• Talk to your healthcare provider about birth control methods that may be right for you.
• If you are able to become pregnant, your healthcare provider will check your pregnancy status before you start treatment with CABOMETYX.
• If you become pregnant or think you are pregnant, tell your healthcare provider right away.
• Are breastfeeding or plan to breastfeed. It is not known if CABOMETYX passes into your breast milk. Do not breastfeed during treatment and for 4 months after your final dose of CABOMETYX.

Interactions

Effects of other drugs on CABOMETYX

Strong CYP3A4 inhibitors

• The co-administration of Cabozantinib capsule formulations and strong CYP3A4 inhibitors increases the exposure of cabozantinib, which may increase the risk of exposure-related adverse reactions. Avoid co-administration of CABOMETYX with strong CYP3A4 inhibitors.
• If co-administration with a strong CYP3A4 inhibitor cannot be avoided, reduce the dose of CABOMETYX. Avoid grapefruit or grapefruit juice, which will also increase the exposure of cabozantinib.
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Strong CYP3A Inducers

• Co-administration of Cabozantinib capsule preparations and strong CYP3A4 inducers can reduce cabozantinib exposure, which may reduce efficacy [see Clinical Pharmacology].
• Avoid co-administration of CABOMETYX with strong CYP3A4 inducers. If co-administration with strong CYP3A4 inducers cannot be avoided, increase the dose of CABOMETYX. Avoid using St. John’s Wort, which can also reduce the exposure of cabozantinib. Cabometyx Cabozantinib 60 mg Tablet price in india best at Yourmedikart and uses treat various types of cancer

FAQ

Is Cabometyx a chemotherapy?

Cabometyx (Cabotinib) is a chemotherapy drug used to treat patients with advanced renal cell carcinoma (kidney cancer) and patients with hepatocellular carcinoma (liver cancer) previously treated with NEXAVAR (Sorafenib). Take it once a day.

Does Cabometyx cure cancer?

No, Cabometyx cannot cure cancer. It is approved for the treatment of renal cell carcinoma (a type of kidney cancer) and hepatocellular carcinoma (a type of liver cancer).

What does Cabometyx treat?

Cabozantinib (Cabometyx) is used to treat advanced renal cell carcinoma (RCC; a cancer that starts in kidney cells). It is also used with nivolumab (Opdivo) to treat advanced RCC that has not yet been treated for RCC.

How effective is Cabometyx?

The primary endpoint of the trial is progression-free survival, with a median of 8.2 months for Cabometyx™ and a median of 5.6 months for sunitinib. Compared with sunitinib, Cabometyx ™ reduces disease progression or mortality by 34%.

Does Cabometyx cause hair loss?

Temporary hair loss may occur. After the treatment is complete, normal hair growth should reappear. People who use this drug may have serious side effects.