Phesgo Pertuzumab Trastuzumab Injection

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Phesgo Injection Dosing manufacturer Pertuzumab Trastuzumab manufactured by Roche | Used in combination who have HER2-positive breast cancer

Phesgo

Manufacturer : Roche

Generic Name : Pertuzumab Trastuzumab Injection

Pertuzumab / Trastuzumab / Hyaluronidase is a generic name for drug name Phesgo manufacturer. In some cases, health care professionals can use trade names or generic names when referring to drugs.

Pertuzumab, Trastuzumab, and Hyaluronidase is targeted therapy. This drug is classified as antineoplastic agents and anti-monoclonal antibodies.

PHESGO  is a prescription medicine approved for use in combination with chemotherapy for:

  • use prior to surgery (neoadjuvant treatment) in adults with HER2-positive, locally advanced, inflammatory, or early stage breast cancer (tumor is greater than 2 cm in diameter or node-positive). PHESGO should be used as part of a complete treatment regimen for early breast cancer.
  • use after surgery (adjuvant treatment) in adults with HER2-positive early breast cancer that has a high likelihood of coming back.

PHESGO  is a prescription medicine approved for use in combination with docetaxel in adults who have HER2-positive breast cancer that has spread to different parts of the body (metastatic) and who have not received anti-HER2 therapy or chemotherapy for metastatic breast cancer.

What is Phesgo Pertuzumab Trastuzumab Used For

Early breast cancer

Used in combination with chemotherapy in adults with HER2 +, advanced breast cancer, inflammation, or early stage breast cancer (EBC). In combination with chemotherapy that occurs after surgery in HER2 + adults with high risk of recurrence.

Metastatic breast cancer

Used in combination with Docetaxel for Her2 + adults with metastatic breast cancer that has not received previous anti-her2 therapy or previous chemotherapy in metastasis settings.

If the drug has been approved for one use, the doctor can choose to use this same medicine for other problems if they believe it may be useful.

How Phesgo Pertuzumab, Trastuzumab and Hyaluronidase Works

  • Cancer is a disease caused by changes, also known as mutations, in DNA which changes the way cells grow and divide. Cancer cells can be destroyed using various types of drugs that work in a very different way. However, Examples of drugs that destroy cancer cells include cytotoxic chemotherapy, targeted therapy, immunotherapy, and antibody drug conjugates.
  • The immune system uses antibodies to protect the body against foreign substances. Antibodies are proteins attached to certain types of protein called antigens. When antibodies find antigens, it triggers the immune system to destroy cells that have antigens. Researchers can make antibodies in the laboratory targeting specific antigens as found in cancer cells. These antibodies are made in the lab call monoclonal antibodies.
  • Monoclonal antibodies target specific differences in cancer cells than normal cells. Because monoclonal antibodies have a special target for cancer cells, they can cause less toxicity for healthy cells. Each type of monoclonal antibody works slightly different, but all disturbs the ability of cancer cells to grow, divide, repair and / or communicate with other cells.
  • PHESGO  contains two separate monoclonal antibodies, Trastuzumab and Pertuzumab. Previously, Trastuzumab and Pertuzumab were used separately or in combination to provide anti-cancer treatment. PHESGO combines these two separate monoclonal antibodies into single injection to use.
  • Trastuzumab and Pertuzumab are the second monoclonal antibodies targeting proteins called HER2 in cancer cells; However, they bind to various sites on proteins. When bound, these agents work together to inhibit the growth of cancer cells and cause cancer cell death.
  • The addition of hyaluronidase-zzxf to combination drugs allows for trastuzumab and pertuzumab is easier to absorb into the bloodstream. It does not have an anti-cancer effect.

Self-care tips

Self-care tips

  • Drink at least two to three quarts of liquid every 24 hours, unless you are instruct otherwise.
  • You may be at risk of infection so try to avoid crowds or people with colds, and report fever or signs of other infections immediately to your health service provider.
  • Wash your hands as often as possible.
  • Use an electric razor and soft toothbrush to minimize bleeding.
  • Avoid sports contact or activities that can cause injury.
  • To reduce nausea, take anti-nausea medicine as prescribed by your doctor, and eat small, often eat.
  • Follow the anti-diarrhea drug regimen as prescribed by your health care professionals.
  • Eating foods that can help reduce diarrhea
  • Avoid sun exposure. Wear SPF 30 (or higher) sunscreen and protective clothing.
  • In general, drinking alcoholic drinks must maintain to a minimum or fully avoid. You have to discuss this with your doctor.
  • Take a lot of rest.
  • Maintain good nutrition.
  • Stay active as you can. Gentle exercises are encourage like daily walk.

If you experience symptoms or side effects, be sure to discuss it with your health care team. Because They can prescribe medicines and / or offer other advice effective in managing the problem.

Precautions

  • Before starting pertuzumab, trastuzumab, and Hyaluronidase treatment, make sure you tell your doctor about other drugs that you take (including prescription, over-the-counter, vitamins, herbal medicines, etc.) Don’t take aspirin, products containing aspirin except doctors You specifically allow this.
  • Pertuzumab, Trastuzumab, and Hyaluronidase have know to have an increase risk of neutropenia when given with myelosuppressive chemotherapy.
  • Thirdly Tell your health care professionals if you are pregnant or maybe get pregnant before starting this treatment. This drug should not give to pregnant women or women who intend to pregnant. Moreover If you are pregnant when taking pertuzumab, trastuzumab, and Hyaluronidase, stop taking medicine immediately and contact your doctor for further instructions.
  • Pertuzumab, trastuzumab, and Hyaluronidase are know to cause embryo-fetal toxicity up to 7 months after injection. Similarly In potential reproductive women, effective contraception must be use during therapy and for 7 months after the last dose.

Phesgo Pertuzumab Trastuzumab Side Effects

  • Important things to remember about the side effects of pertuzumab, trastuzumab, and Hyaluronidase:
  • Most people will not experience all side effects listed.
  • Pertuzumab side effects, trastuzumab, and Hyaluronidase can often be predict in terms of onset, duration, and severity.
  • Most side effects will improve after therapy is complete.
  • There are many options to minimize or prevent side effects from Pertuzumab, Trastuzumab, and Hyaluronidase.

Common Occurring Side Effects in greater than 30%

  • Skin Reactions (Rash, dry skin)
  • Anemia
  • General Weakness
  • Diarrhea
  • Hair loss
  • Neutropenia
  • Nausea
  • Fatigue
  • Peripheral Neuropathy

Common Occurring Side Effects in greater than 10-29%

  • Cough
  • Decreased Appetite
  • Thrombocytopenia
  • Constipation
  • Dizziness
  • Vomiting
  • Headache
  • Injection Reaction

These are rare serious side effects

  • Embryo-Fetal Toxicity
  • Pulmonary toxicity
  • Hypersensitivity or Administration-Related Reactions
  • Cardiomyopathy

Receiving PHESGO dosing during pregnancy can result in the death of an unborn baby and birth defects.

  • Birth control should use while receiving PHESGO injection dosing and for 7 months after your last dose of PHESGO dosing manufacturer. For Instance, If you are a mother who is breastfeeding, you should talk with your doctor about either stopping breastfeeding or stopping PHESGO
  • Secondly you think you may be pregnant, you should contact your healthcare provider immediately
  • If you are expose to PHESGO during pregnancy, or become pregnant while receiving PHESGO manufacturer or within 7 months following the last dose of PHESGO Injection.

What are the most serious side effects of Phesgo injection?

PHESGO may cause heart problems, including those without symptoms (such as reduced heart function) and those with symptoms (such as congestive heart failure).

  • Firstly The risk for and seriousness of these heart problems are highest in people who received both PHESGO manufacturer manufacturer and a certain type of chemotherapy (anthracycline)
  • Your doctor will check for signs of heart problems before, during, and after treatment with PHESGO. Based on test results, your doctor may hold or discontinue treatment with PHESGO
  • Contact a healthcare professional immediately for any of the following: new onset or worsening shortness of breath, cough, swelling of the ankles/legs, swelling of the face, palpitations, weight gain of more than 5 pounds in 24 hours, dizziness or loss of consciousness

What are other possible serious side effects?

  • PHESGO may worsen low white blood cell counts caused by chemotherapy: Low white blood cell counts can be life threatening and were see. More often in patients receiving Herceptin (trastuzumab) plus chemotherapy than in patients receiving chemotherapy alone. In Other Words Your doctor may check for signs of low white blood cell counts when he or she examines you
  • PHESGO may cause administration-related reactions: PHESGO manufacturer dosing is give as an injection. So The active ingredients in PHESGO dosing have  associate with severe administration reactions, including hypersensitivity or anaphylaxis, which can be fatal. Talk to your doctor if you feel any symptoms. The most common symptoms include dizziness, nausea, chills, fever. However, vomiting, diarrhea, hives, swelling of the skin, breathing problems, or chest pain
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