Nucala 100 Mg/Vial

GSK

Generic Name : Mepolizumab

What is Nucala 100 mg used for and Nucala Injection Cost?

NUCALA is a medication which contains the active substance mepolizumab, a monoclonal antibody. This antibody blocks a particular protein called interleukin-5. By blocking the activity of interleukin-5, NUCALA limits the production of more eosinophils (a kind of white platelet) from the bone marrow and brings down the quantity of eosinophils in the bloodstream and the lungs. Nucala 100 mg price in india is low. Cost of mepolizumab is low at yourmedikart.store

NUCALA is used to treat severe eosinophilic asthma or to treat eosinophilic granulomatosis with polyangiitis (EGPA).

Severe eosinophilic asthma

Some people with severe asthma have an excessive number of eosinophils (a type of white platelet) in the blood, lungs and tissues. Having such a large number of eosinophils in your blood can harm the airways and can make your asthma to get worse or can expand the quantity of your asthma flare ups.

NUCALA is used to treat asthma by diminishing the frequency of asthma flare ups in adolescents (more than 12 years old) and adults who are now accepting asthma medicines, but whose asthma flare ups are not very much controlled by medicines, for example, high-dose corticosteroid inhalers or beta-agonist inhalers.

NUCALA can also be used to help diminish the every day dose of oral corticosteroids in patients taking these prescriptions to control asthma symptoms and flare ups.

Eosinophilic Granulomatosis with Polyangiitis (EGPA)

EGPA is a condition where people have such a large number of eosinophils in the blood and tissues, and furthermore have inflammation of the veins (vasculitis). EGPA most usually affects the lungs and sinuses however regularly affects different organs including the skin, heart, kidneys, nerves or bowels.

NUCALA can decrease symptoms and delay a flare-up of these indications in people who are now taking corticosteroids.

NUCALA can also help lessen the day by day dose of corticosteroids you need to control your side effects.

Ask your doctor if you have any questions about why this medicine has been prescribed for you.

This medication is available just with a doctor’s prescription.

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Description

Mepolizumab is a humanized IL-5 antagonist monoclonal antibody. Mepolizumab is produced in Chinese hamster ovary cells through recombinant DNA technology. The molecular weight of mepolizumab is approximately 149 kDa.

NUCALA is provided as a sterile, white to off-white, freeze-dried powder without preservatives, and is used for subcutaneous injection after reconstitution. Use 1.2 ml of sterile water for injection, USP after reconstitution, the resulting concentration is 100 mg/ml, and 1 ml is obtained. Each single-dose vial releases 100 mg of mepolizumab, polysorbate 80 (0.67 mg), sodium hydrogen phosphate heptahydrate (7.14 mg) and sucrose (160 mg), with a pH of 7.0.

How to use Nucala 100 Mg

NUCALA is given by injection under your skin (subcutaneous injection).

This is a solution for infusion in pre-filled pen (auto-injector) which can be given either by you, your guardian or a doctor/nurse.

Your doctor or nurse will choose if you or your parental figure can inject NUCALA. If they consider self -administration appropriate, your doctor or medical caretaker will provide training to show you or your parental figure the right method to use NUCALA.

You can inject NUCALA under your skin in either your stomach area (abdomen) or upper leg (thigh). Your parental figure can inject NUCALA at these sites or into your upper arm. You should not give injections into areas where the skin is tender, bruised, red, or hard.

Like all prescriptions, NUCALA can cause side effects, although not every person gets them. The side effects brought about by NUCALA are usually mild to moderate but can occasionally be serious.

Try not to be frightened by the following list of side effects. You may not experience any of them.

Ask your doctor or drug specialist to answer any inquiries you may have.

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Very common side effects

This may affect more than 1 out of 10 people:

• headache

Common side effects

These may affect up to 1 in 10 people:

• urinary tract infection (blood in urine, painful and frequent urination, fever, pain in lower back)
• lower respiratory tract infection
• eczema
• fever
• headache, injection site reactions, diarrhea and vomiting.
• nasal congestion
• injection-site reaction (pain, redness, swelling, itching, and burning sensation of the skin near where the injection was given)
• pharyngitis (sore throat)
• back pain

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Dosage and Administration

NUCALA is for subcutaneous use only in adults and adolescents with severe asthma 12 years and older. The recommended dose of NUCALA for adults and adolescents 12 years and older is 100 mg, once every 4 weeks, by subcutaneous injection in the upper arm, thigh, or abdomen [see for Preparation and administration of NUCALA for injection vials and preparation and administration of NUCALA injection pre-filled auto-injector and pre-filled syringe]. The recommended dose of NUCALA injection for children 6 to 11 years old for children 6 to 11 years old is 40 mg once every 4 years. Inject subcutaneously in the upper arm, thigh or abdomen for several weeks.

The recommended dose of NUCALA for eosinophilic granuloma with polyangiitis is 300 mg, subcutaneously injected every 4 weeks, and 100 mg is injected separately into the upper arm, thigh or abdomen in 3 separate doses [see the preparation and administration and preparation of NUCALA in the injection bottle and Administration of NUCALA injection pre-filled auto-injector and pre-filled syringe]. Inject 100 mg separately, at least 5 cm (approximately 2 inches) apart.

The recommended dose for hypereosinophilic syndrome is 300 mg. Top of the abdomen [see Preparation and administration of NUCALA for injection vials and preparation and administration of pre-filled auto injectors and pre-filled syringes for injection of NUCALA]. Inject 100 mg separately, at least 5 cm (approximately 2 inches) apart.

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Warnings

Hypersensitivity reactions (eg, angioedema, bronchospasm, hypotension, urticaria, rash) reported; those reactions usually arise inside hours of administration, however in a few times will have a not on time onset (ie, days); stop drug with inside the occasion of a allergy reaction

Not for treatment of acute asthma symptoms or acute exacerbations; do not use to treat acute bronchospasm or status asthmaticus; instruct patients to seek immediate medical advice if their asthma remains uncontrolled or worsens after initiating mepolizumab

In clinical trials, 2 serious adverse reactions of herpes zoster occurred during treatment compared with none in placebo; consider varicella vaccination if medically appropriate before initiating treatment

Do not discontinue systemic or inhaled corticosteroids abruptly upon initiation mepolizumab; reductions in corticosteroid dose, if appropriate, should be gradual and performed under the direct supervision of a physician; reduction in corticosteroid dose may be associated with systemic withdrawal symptoms and/or unmask conditions previously suppressed by systemic corticosteroid therapy

Eosinophils may be involved in the immunological response to some helminth infections; patients with known parasitic infections were excluded from participation in clinical trials; treat patients with preexisting helminth infection before initiating mepolizumab; if helminth infection occurs while receiving mepolizumab that does not respond to treatment, discontinue mepolizumab until the infection resolves.

FAQ

What is Nucala used for?

NUCALA is an alternate kind of treatment for your severe asthma. It's an injection you get every 4 weeks in your doctor's clinic or take at home. When added to your present asthma meds, NUCALA may diminish airway inflammation that can cause severe asthma attacks.

How quickly does Nucala work?

Nucala begins working within 48 hours; however, it might require as long as about a month before the maximum effect of Nucala is seen for both asthma and eosinophilic granulomatosis with polyangiitis (EGPA).

How long should I take Nucala?

Nucala is given once every four weeks. Xolair might be given once every two weeks or once every four weeks. The dosage depends upon your age, body weight, and IgE level before starting treatment.

Does Nucala lower immune system?

Expanded infections (infections identified with alteration in immune response) Nucala brings down the body's levels of certain white platelets, called eosinophils, and patients with low white platelet checks have a higher possibility of developing an infection.

Is Nucala safe?

Nucala In Children The safety and efficacy of Nucala for severe asthma, and with an eosinophilic phenotype, have been set up in pediatric patients matured 6 years and older. The safety and efficacy of Nucala in pediatric patients aged younger than 6 years with severe asthma have not been set up.