Tabrecta Capmatinib 200 mg capmatinib price in india

Generic Name: Capmatinib tablets

Brand Name: Tabrecta

Drug Class: MET Tyrosine Kinase Inhibitors

What is Tabrecta?

Tabrecta is a prescription medicine used to treat adults with a kind of lung cancer called non-small cell lung cancer (NSCLC) that:

• Has spread to other parts of the body or cannot be removed by surgery (metastatic), and
• Whose tumors have an abnormal mesenchymal epithelial transition (MET) gene.

It is not known if this medicine is safe and effective in children.

How should I store Tabrecta?

• Store Tabrecta at room temperature between 68°F to 77°F (20°C to 25°C).
• Store tablets in the original package with the drying agent (desiccant) cartridge.
• Protect the tablets from moisture.
• Throw away (discard) any unused Tabrecta you have left after 6 weeks of first opening the bottle.

Keepall medicines out of the reach of children and pets.

Uses for Tabrecta

TABRECTA is indicated for the treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have a mutation that leads to mesenchymal-epithelial transition (MET) exon 14 skipping as detected by an FDA-approved test.

Precautions

• Before taking capmatinib, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
• Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, lung problems, disease of the pancreas (pancreatitis).
• Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
• This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness. Ask your doctor for details.
• Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, capmatinib price in india women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets.

How should I take Tabrecta?

• Take Tabrecta exactly as your healthcare provider tells you.
• Take Tabrecta tablets 2 times a day with or without food.
• Swallow the tablets whole. Do not break, chew, or crush the tablets.
• Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment if you have certain side effects.
• Do not change your dose or stop treatment unless your healthcare provider tells you to.
• If you miss or vomit a dose, do not make up the dose. Take your next dose at your regular scheduled time.

What are the ingredients in Tabrecta?

Active ingredient: capmatinib
Inactive ingredients: Tablet core: colloidal silicon dioxide; Crospovidone; magnesium stearate; mannitol; microcrystalline cellulose; povidone; and sodium lauryl sulfate.
Tablet coating (150 mg): ferric oxide, red; ferric oxide, yellow; Ferrosoferric oxide; Hypromellose; polyethylene glycol (PEG) 4000; talc; and titanium dioxide.
Tablet coating (200 mg): ferric oxide, yellow; Hypromellose; polyethylene glycol (PEG) 4000; talc; and titanium dioxide.

Before taking Tabrecta

Before taking Tabrecta, tell your healthcare provider about all of your medical conditions, including if you:

• • Have or have had lung or breathing problems other than your lung cancer.
  • Have or have had liver problems.
  • Are pregnant or plan to become pregnant. Tabrecta can harm your unborn baby.
    Females who are able to become pregnant:
    • Your healthcare provider should do a pregnancy test before you start treatment.
    • You should use effective birth control during treatment and for 1 week after your last dose. Talk to your healthcare provider about birth control choices that might be right for you during this time.
    • Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment.

    Males who have female partners who can become pregnant:

    • You should use effective birth control during treatment and for 1 week after your last dose.

are breastfeeding or plan to breastfeed. It is not known if Tabrecta passes into your breast milk. Do not breastfeed during treatment and for 1 week after your last dose.

What are the possible side effects of Tabrecta?

Tabrecta may cause serious side effects, including:

• Lung or breathing problems. Tabrecta may cause inflammation of the lungs that can cause death. Tell your healthcare provider right away if you develop any new or worsening symptoms, including:
  • Cough
  • Fever
  • Trouble Breathing or Shortness of Breath

  Your healthcare provider may temporarily stop or permanently stop Tabrecta if you develop lung or breathing problems during treatment.

• liver problems. Tabrecta may cause abnormal liver blood test results. Your healthcare provider will do blood tests to check your liver function before you start, and during treatment. Tell your healthcare provider right away if you develop any signs and symptoms of liver problems, including:
  • Your skin or the white part of your eyes turns yellow (jaundice)
  • Loss of appetite for several days or longer
  • Dark or “tea-colored” urine
  • Nausea and vomiting
  • Light-colored stools (bowel movements)
  • Confusion
  • Pain, aching, or tenderness on the right side of your stomach-area (abdomen)
  • Tiredness
  • Weakness
  • Swelling in your stomach-area

  Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment if you develop liver problems.

• risk of sensitivity to sunlight (photosensitivity). Tabrecta Capmatinib price in india See What should I avoid while taking Tabrecta?

The most common side effects include:

• Swelling of your hands or feet
• Nausea
• Tiredness and weakness
• Vomiting
• Loss of appetite
• Changes in certain blood tests

What to avoid

• Your skin may be sensitive to the sun (photosensitivity) during treatment. Use sunscreen or wear clothes that cover your skin during your treatment to limit direct sunlight exposure.

Warnings and Precautions

Precautions

Interstitial Lung Disease (IP)/Pneumonia Pneumonia/IP can fatal and occurs in patients treated with TABRECTA [see Contraindications]. GEOMETRY mono-1 developed ILD/pneumonia in 4.5% of patients treated with this drug, 1.8% of patients developed grade 3 ILD/pneumonia and one patient died (0.3%).  Similarly capmatinib 200 mg tablet price The median time to onset of grade 3 or higher ILD/pneumonia was 1.4 months (range: 0.2 months to 1.2 years).

Look for signs of new or Worsening lung disease (such as Shortness of breath, cough, fever) indicating ILD/Pneumonia. Meanwhile Stop this drug Immediately capmatinib 200 mg tablet for Patients with Suspected ILD/pneumonia. Tabrecta 200 mg Permanent exclusion unless other causes of PID/pneumonia have identified [see Medication Administration and Control].

Hepatotoxicity

Hepatotoxicity occurs in patients treated with Tabrecta Capmatinib 200 mg [see Adverse Reactions].3 patients (0.9%) were discontinued from this treatment. The average height of grade 3 or higher ALT/AST was 1.4 months (maximum: 0.5 to 4.1 months). Monitor liver function (including ALT, capmatinib price in india AST and total bilirubin) capmatinib price in india before starting, every 2 weeks for the first 3 months of treatment, then monthly for patients with high dose Tabrecta Capmatinib price in india transaminases or on treatment or frequent bilirubin. Discontinue, reduce dose, or discontinue However, TABRECTA permanently depending on severity of reaction [see Dosage and Administration].

Photosensitivity Hazards

According to the results of animal studies, Tabrecta Capmatinib 200 mg has a potential risk of photosensitivity capmatinib price in india [see Non-Clinical Toxicology]. In GEOMETRY mono-1, patients are advised to take preventive measures to prevent UV exposure, such as wearing sunscreen or protective clothing during So treatment. Because it is recommended that patients limit direct UV exposure during TABRECTA treatment.

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FAQ

What is Tabrecta used for?

Tabrecta is a medicine used to treat adults with a type of lung cancer called non-small cell lung cancer (NSCLC), when the cancer has progressed, and the cells have mutated hereditary (transformation) that leads to mesenchymal-epithelial transition. gene exon 14 (METEx14).

How effective is the Tabrecta?

In a second study, the overall response rate (ORR) to Tabrecta in 60 treatment-naïve patients with non-small cell lung cancer (NSCLC) was 68%, and half of the patients in -achieve a response time of 16.6 months.

Is Tabrecta an immunotherapy?

Tabrecta (capmatinib) is a targeted chemotherapy drug.

Is Tabrecta a chemo drug?

No, Tabrecta is not a chemotherapy drug. Chemotherapy drugs work by killing rapidly growing cells. Cancer cells grow faster than healthy cells. That is why chemotherapy drugs are effective in treating cancer.

Is immunotherapy better than chemo?

Immunotherapy teaches healthy cells to recognize cancer cells and stop them from growing. Simply put, chemotherapy directly destroys cancer cells and tumors, while immunotherapy allows the immune system to work more effectively and fight the cancer itself. him.