Fetroja (Cefiderocol) Injection 1gm

Brand: Fetroja® | Generic: Cefiderocol | Inj. Cefiderocol 1gm | Manufacturer: Shionogi Inc. Drug class: Siderophore Cephalosporin Antibiotic Prescription-only. Available to hospitals, specialist centers, and licensed institutional buyers across India.

 

Overview

Fetroja is a brand name for cefiderocol, a next-generation siderophore cephalosporin antibiotic developed by Shionogi for the treatment of serious multidrug-resistant (MDR) Gram-negative bacterial infections. It is prescribed in adults where limited or no alternative treatment options exist — making it a last-resort antibiotic for critically ill patients, typically in ICU and hospital settings.

Demand for cefiderocol in India has grown steadily as carbapenem-resistant infections become more prevalent in critical care. YourMedikart supplies genuine Fetroja injection in India to hospitals, critical-care pharmacies, and authorized institutional buyers. As Fetroja is not yet centrally registered in India, procurement is facilitated through Named Patient Import with a valid prescription and institutional documentation.

For current cefiderocol price in India or Fetroja price enquiries, use the contact form below — pricing depends on order volume and import route.

Fetroja Injection (Cefiderocol 1g) is a prescription-only cefiderocol antibiotic supplied as a sterile cefiderocol vial for intravenous administration in hospitals under the supervision of qualified healthcare professionals. Fetroja, also known in some regions as Fetcroja, contains cefiderocol, a novel siderophore cephalosporin antibiotic used for the treatment of serious infections caused by multidrug-resistant Gram-negative bacteria when other treatment options are limited. It is sometimes searched as inj Fetroja, cefiderocol injection, or cefiderocol generation because of its unique mechanism of bacterial cell entry. If you are searching for cefiderocol India, cefiderocol price, cefiderocol injection price, cefiderocol pret, cefiderocol precio, cefiderocol cena, cefiderocol цена, or Fetroja injection price in Pakistan, pricing may vary depending on country, availability, import regulations, and supplier. Contact YourMediKart for the latest availability, genuine product sourcing, and quotation for Fetroja injection. This medicine should only be used on the advice of an infectious disease specialist or other qualified physician and administered according to approved clinical guidelines.

Fetroja Injection Uses

Fetroja (cefiderocol) is indicated in adults (18 years and older) with limited or no alternative options for:

Complicated Urinary Tract Infections (cUTI), including Pyelonephritis Caused by susceptible Gram-negative organisms including Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, and Enterobacter cloacae complex.

Hospital-Acquired Bacterial Pneumonia (HABP) and Ventilator-Associated Bacterial Pneumonia (VABP) Caused by susceptible Gram-negative organisms including Acinetobacter baumannii complex, E. coli, Enterobacter cloacae complex, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Serratia marcescens.

To reduce the development of drug-resistant bacteria, Fetroja should only be used to treat infections that are proven or strongly suspected to be caused by susceptible bacteria.

Cefiderocol Mechanism of Action

Cefiderocol is a siderophore cephalosporin — a class distinct from other beta-lactams. It uses a unique iron-transport “Trojan horse” mechanism: the cefiderocol molecule binds to ferric iron and is actively transported across the outer membrane of Gram-negative bacteria through the bacteria’s own iron-uptake channels (siderophore transporters). Once inside the periplasmic space, cefiderocol binds to penicillin-binding proteins (PBPs), particularly PBP3, inhibiting bacterial cell wall synthesis and causing cell death.

This mechanism allows cefiderocol to bypass the outer-membrane impermeability and efflux pump resistance mechanisms that defeat most other beta-lactams — including carbapenems — making it effective against carbapenem-resistant Enterobacterales (CRE), carbapenem-resistant Pseudomonas aeruginosa, and Acinetobacter baumannii complex.

 

Fetroja (Cefiderocol) 1g Injection is a novel fetroja antibiotic containing cefiderocol, a next-generation siderophore cephalosporin developed for the treatment of serious multidrug-resistant Gram-negative bacterial infections. Common fetroja injection uses include hospital management of complicated urinary tract infections (cUTI), hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and infections caused by carbapenem-resistant organisms when other treatment options are limited. Fetroja injection is administered as a fetroja IV infusion under the supervision of a healthcare professional. If you are searching for cefiderocol injection, cefiderocol price, fetroja price, cefiderocol cost, or fetroja cost, YourMediKart offers reliable information and assistance regarding availability. Many international buyers also search for terms such as cefiderocol pret, cefiderocol precio, cefiderocol cena, fetroja precio, fetcroja cena, and fetcroja 1 g pret when comparing prices across regions. As a modern cefiderocol generation antibiotic, Fetroja has become an important option against difficult-to-treat bacterial infections. We also provide information regarding cefiderocol availability in India and can assist customers looking for cefiderocol in Pakistan, subject to applicable regulations and prescription requirements. Contact us to learn more about Fetroja (Cefiderocol) 1g Injection, pricing, availability, and international shipping options.

 

Fetroja Coverage — Antimicrobial Spectrum

Fetroja (cefiderocol) has demonstrated in vitro activity against a broad range of Gram-negative bacteria, including many that are resistant to carbapenems and other last-line antibiotics. Fetroja coverage includes:

Enterobacterales

• Escherichia coli (including ESBL and carbapenem-resistant strains)
• Klebsiella pneumoniae (including KPC, OXA-48, NDM producers)
• Enterobacter cloacae complex
• Proteus mirabilis
• Serratia marcescens
• Citrobacter spp.

Non-Fermenters (most clinically significant)

• Pseudomonas aeruginosa (including MBL-producing, carbapenem-resistant strains)
• Acinetobacter baumannii complex (including pan-drug-resistant strains)
• Stenotrophomonas maltophilia
• Burkholderia cepacia complex

Key Resistance Profiles Covered Fetroja retains activity against bacteria producing major carbapenemases including KPC (Klebsiella pneumoniae carbapenemase), MBLs (NDM, VIM, IMP), and OXA-type carbapenemases — the resistance mechanisms that defeat meropenem, imipenem, and colistin in many clinical isolates.

Coverage Gaps Fetroja does not cover Gram-positive bacteria (Staphylococcus, Streptococcus, Enterococcus) or anaerobes. It is not indicated for MRSA, VRE, or polymicrobial infections without susceptibility confirmation for the Gram-negative component.

In vitro activity does not always predict clinical outcome. Susceptibility testing prior to use is recommended where feasible.

Product Details

Generic Name	Cefiderocol
Brand Name	Fetroja®
Manufacturer	Shionogi Inc.
Pack Size	1 gram per single-dose vial
Drug Class	Siderophore cephalosporin (antibacterial)
Route of Administration	Intravenous (IV) infusion over 3 hours
Storage	Refrigerated 2°C–8°C, protected from light
FDA Approval	November 2019

Dosage

The standard adult dose of Fetroja is 2 grams IV every 8 hours, infused over 3 hours, in patients with creatinine clearance (CLcr) 60–119 mL/min. Renal dose adjustments apply for CLcr below 60 mL/min or above 120 mL/min.

CLcr (mL/min)		Dose	Frequency
≥120		2g	Every 6 hours
60–119		2g	Every 8 hours
30–59		1.5g	Every 8 hours
15–29		1g	Every 8 hours
<15 (no dialysis)		0.75g	Every 8 hours
Intermittent HD		0.75g	Every 12 hours

Treatment duration is typically 7–14 days for cUTI and 14 days for HABP/VABP (up to 21 days for immunocompromised patients).

Preparation & Administration

• Reconstitute the 1gm vial with 10 mL of either 0.9% sodium chloride or 5% dextrose injection.
• Gently swirl — do not shake. Allow foam to subside (~2 minutes) before proceeding.
• Further dilute into an IV bag (0.9% NaCl or 5% dextrose) for infusion.
• Infuse over exactly 3 hours. Do not administer as an IV push or bolus.
• After mixing into the IV bag: use within 6 hours at room temperature, or within 24 hours if refrigerated (protected from light).
• After removal from refrigerator: use within 6 hours once at room temperature.
• Each vial and IV bag is single-use only. Discard any unused portion.

Boxed Warning & Precautions

⚠ Increased All-Cause Mortality (Boxed Warning)

In a clinical study (NCT02714595), higher 28-day all-cause mortality was observed in Fetroja-treated patients with carbapenem-resistant Gram-negative infections (nosocomial pneumonia, bloodstream infections, or sepsis) compared to best available therapy (BAT). Most BAT regimens contained colistin. Mortality remained higher through Day 49. Deaths were predominantly in patients with infections caused by non-fermenters including Acinetobacter baumannii complex, Stenotrophomonas maltophilia, and Pseudomonas aeruginosa, resulting from worsening infection or underlying comorbidities.

Clinical response must be closely monitored in all Fetroja-treated patients.

Hypersensitivity Reactions

Serious, occasionally fatal anaphylactic reactions and serious skin reactions have been reported with beta-lactam antibacterials including Fetroja. Before use, assess history of allergy to cephalosporins, penicillins, or other beta-lactams. Discontinue immediately if an allergic reaction occurs.

Clostridioides difficile-Associated Diarrhea (CDAD)

CDAD has been reported with Fetroja and may occur months after treatment ends. If suspected, discontinue Fetroja and manage appropriately.

CNS Effects

Seizures, encephalopathy, coma, asterixis, and neuromuscular excitability have been reported with cephalosporins, particularly with renal impairment or dose errors. Adjust dose based on CLcr. Evaluate for discontinuation if focal tremors or seizures occur.

Antimicrobial Resistance

Prescribing Fetroja without a proven or strongly suspected susceptible bacterial infection increases the risk of drug-resistant bacteria development.

Side Effects

Serious (seek immediate help)

• Signs of severe allergic reaction: hives, difficulty breathing, swelling of face or throat
• Severe skin reaction: fever, sore throat, burning eyes, skin pain, spreading blistering rash
• Watery or bloody diarrhea — even months after last dose (C. diff)
• Tremor, rigid muscles, or seizure

Common (≥2% in clinical trials)

cUTI trial: Diarrhea (4%), infusion site reactions (4%), constipation (3%), rash (3%), candidiasis (2%), cough (2%), elevated liver tests (2%), headache (2%), hypokalemia (2%), nausea (2%), vomiting (2%).

HABP/VABP trial: Elevated liver tests (16%), hypokalemia (11%), diarrhea (9%), hypomagnesemia (5%), atrial fibrillation (5%).

Before Using Fetroja

Do not use if you have had a severe allergic reaction to:

• Any cephalosporin (cefadroxil, cefdinir, ceftriaxone, cephalexin, etc.)
• Any penicillin (amoxicillin, ampicillin, etc.)
• Beta-lactamase inhibitor combinations (avibactam, tazobactam, etc.)

Tell your doctor if you have: kidney disease, a history of seizures, liver disease, or intestinal conditions such as colitis.

Pregnancy & Breastfeeding: Fetroja’s effects on the fetus are unknown. It is also unknown whether cefiderocol passes into breast milk. Consult your doctor before use if pregnant or breastfeeding.

Paediatric use: Safety and efficacy in patients under 18 have not been established.

Drug Interactions

Fetroja may interact with other medications. Inform your doctor of all medicines, supplements, and herbal products you are using. Specific interactions should be reviewed against the full prescribing information.

Storage

Store vials in the original carton, refrigerated (2°C–8°C). Protect from light. Do not freeze.

How to Buy Fetroja in India

Hospitals, ICUs, and licensed pharmacies looking to buy Fetroja in India can do so through YourMedikart’s specialist import supply channel. As cefiderocol is accessed via Named Patient Import in India, the following documentation is required to process an order:

• Valid prescription from a Registered Medical Practitioner (RMP)
• Patient diagnostic reports confirming indication
• Patient ID proof (government-issued)
• Import permit (if applicable)

Submit your documentation via the enquiry form below for current Fetroja price in India and estimated delivery lead times. All orders are verified and dispatched by licensed pharmacists.

[Enquire to Buy Fetroja — Request Institutional Pricing]

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FAQ

What is the cefiderocol price in India / Fetroja price in India?

Fetroja is not centrally registered in India and is procured through Named Patient Import. Cefiderocol price in India varies by order volume, import route, and current availability. Institutional buyers — hospitals and licensed pharmacies — can enquire for current Fetroja price via YourMedikart's sourcing team.

What is the cefiderocol brand name in India?

The primary brand name for cefiderocol globally and in India is Fetroja®, manufactured by Shionogi Inc. There is currently no Indian generic or biosimilar brand of cefiderocol available. Fetroja is procured in India through Named Patient Import from international supply chains.

How can I buy Fetroja in India?

To buy Fetroja in India, you require a valid prescription from a Registered Medical Practitioner, patient diagnostic reports, and government-issued patient ID. YourMedikart facilitates the Named Patient Import process — submit your documentation via the enquiry form above for pricing and lead times.

What is the Fetroja coverage (which bacteria does it cover)?

Fetroja covers a broad range of Gram-negative bacteria including carbapenem-resistant Enterobacterales (CRE), Pseudomonas aeruginosa, Acinetobacter baumannii complex, and Stenotrophomonas maltophilia. It does not cover Gram-positive organisms or anaerobes. See the full Fetroja Coverage section above for the complete spectrum.

What generation cephalosporin is cefiderocol?

Cefiderocol is classified as a novel/next-generation siderophore cephalosporin — a distinct subclass not numbered within the standard 1st–5th generation framework. Its iron-transport mechanism sets it apart from all previous cephalosporin generations.

What is Fetroja injection used for?

Fetroja injection is used in adults for complicated urinary tract infections (cUTI) including pyelonephritis, and for hospital-acquired or ventilator-associated bacterial pneumonia (HABP/VABP), when caused by multidrug-resistant Gram-negative bacteria and other treatment options have been exhausted.

Is a generic version of cefiderocol available in India?

No. Fetroja is currently only available as a branded product by Shionogi. No generic cefiderocol is approved or commercially available in India.

How is Fetroja different from carbapenems?

Carbapenems are often the last-line standard for MDR Gram-negative infections, but carbapenem-resistant strains are increasingly common. Cefiderocol's siderophore iron-transport mechanism allows it to penetrate bacteria that have developed outer-membrane impermeability to carbapenems — making it active against CRE, carbapenem-resistant Pseudomonas, and XDR Acinetobacter.

Can Fetroja inj be given as a rapid IV push?

No. Fetroja inj must always be administered as a slow IV infusion over exactly 3 hours. IV push or bolus administration is not permitted.