Cotellic 20 mg

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Generic name: Cobimetinib [ KOE-bi-ME-ti-nib]
Drug class: Multikinase inhibitors

Cotellic (cobimetinib) is an orally administered kinase inhibitor used to treat advanced melanoma

Cotellic Cobimetinib 20 mg price but best at Yourmedikart.

Generic name: Cobimetinib [ KOE-bi-ME-ti-nib]
Drug class: Multikinase inhibitors

Cotellic (cobimetinib) is an orally administered kinase inhibitor used to treat advanced melanoma (skin cancer) in patients with an abnormal genetic marker known as a BRAF V600E or V600K.

Cotellic (cobimetinib) 20 mg, in combination with Zelboraf, presents a significant advancement in the treatment of cancer, offering a new hope to patients. This targeted therapy has shown effectiveness in cases of histiocytosis, where traditional antidotes to cancer fall short. While the cobimetinib price reflects its value in the oncology field, it’s essential for patients and healthcare providers to consider both Cotellic and its counterpart, Zelboraf, for comprehensive care.

Cobimetinib Cotellic

Cotellic is used in combination with vemurafenib (Zelboraf).

BRAF and MEK are proteins in a cell signaling pathway that help control cell growth and survival. Vemurafenib is designed to inhibit some mutated forms of BRAF, and Cotellic is designed to inhibit some forms of MEK. When used in combination, Cotellic Cobimetinib price and vemurafenib are thought to reduce cancer cell growth longer than with vemurafenib alone.

Cotellic is also used to treat histiocytic neoplasms, a group of rare diseases caused by overproduction of the white blood cells called histiocytes. The diseases include Erdheim-Chester disease, Rosai-Dorfman disease, Cobimetinib price and Langerhans cell histiocytosis.

Cotellic 20 mg

What is Cotellic?

Cotellic is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Cotellic Cobimetinib 20 mg is used in adults to treat a certain type of metastatic melanoma (skin cancer) that has Cotellic 20 mg price spread to other parts of the body and cannot be removed with surgery. This medicine is usually given Cobimetinib price together with another medicine called Zelboraf (Vemurafenib).

Cotellic Cobimetinib 20 mg is used only if your tumor has a specific genetic marker, for which your doctor will test.


Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

How should I take Cotellic?

  • Take Cotellic Cobimetinib 20 mg exactly as it was prescribed for you. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.
  • Your doctor will perform tests to make sure Cotellic Cobimetinib 20 mg is the right treatment for you.
  • Cotellic Cobimetinib 20 mg is given in a 28-day treatment cycle. You may need to use the medicine only during the first 21 days of each cycle. Your doctor will determine how long to treat you with Cotellic.
  • Do not change your doses or medication schedule without your doctor’s advice.
  • You may take Cotellic Cobimetinib 20 mg with or without food.
  • If you vomit shortly after taking Cotellic, Cotellic 20 mg price do not take another dose. Take your next dose as scheduled.
  • Check your skin on a regular basis while you are using Cotellic. Tell your doctor if you notice any new skin change such as redness, sores that will not heal, a new wart, or a mole that has changed in size or color.
  • You will need frequent medical tests.
  • Store at room temperature away from moisture and heat.

Before taking Cotellic, tell your doctor:

  • If you are allergic to Cotellic; any part of this medicine; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
  • If you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with Cotellic, like certain drugs that are used for HIV, infections, or seizures. There are many drugs that must not be taken with Cotellic.
  • If you are taking St. John’s wort. Do not take St. John’s wort with Cotellic. This medicine may not work as well.
  • If you are breast-feeding. Do not breast-feed while you take Cotellic and for 2 weeks after your last dose.

This is not a list of all drugs or health problems that interact with this medicine.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Cotellic 20 mg with all of your drugs and health problems. Do not start, Cobimetinib price stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Cotellic?

  • Tell all of your health care providers that you take Cotellic. This includes your doctors, nurses, pharmacists, and dentists.
  • This medicine is use with vemurafenib. Talk with the doctor about the risks and side effects that may happen with vemurafenib.
  • This medicine may add to the chance of getting some types of cancer. Talk with the doctor.
  • You will need to have a skin exam before you start Cotellic 20 mg and every 2 months while you take it. You will also need to do monthly skin checks as told by your doctor.
  • Have an eye exam as you have told by your doctor.
  • Have blood work checked as you have told by the doctor. Talk with the doctor.
  • You may get sunburned more easily. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.
  • High blood pressure has happened with Cotellic. Have your blood pressure check as you have told by your doctor.
  • This medicine may cause heart failure. You will need to have your heart function checked while taking Cotellic. Call your doctor right away if you have signs of heart problems like a cough or shortness of breath that is new or worse, swelling of the ankles or legs, a heartbeat that does not feel normal, weight gain of more than 5 pounds in 24 hours, dizziness, or passing out.
  • A certain muscle problem (rhabdomyolysis) has happened with Cotellic. Rarely, this has led to organ problems and death. Call your doctor right away if you have muscle pain or weakness.
  • This medicine may affect fertility. Fertility problems may lead to not being able to get pregnant or father a child.

How is Cotellic best taken?

Use Cotellic 20 mg as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take with or without food.
  • If you throw up after taking a dose, do not repeat the dose. Take your next dose at your normal time.
  • Keep taking Cotellic Cobimetinib price 20 mg as you have tell by your doctor or other health care provider, even if you feel well.

What do I do if I miss a dose?

  • Skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

What are the side effects of Cotellic that I need to call my doctor about immediately?

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of bleeding like throwing up or coughing up blood; vomit that looks like coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; abnormal vaginal bleeding; bruises without a cause or that get bigger; or bleeding you cannot stop.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Signs of electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, seizures, not hungry, or very bad upset stomach or throwing up.
  • Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
  • Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
  • Dizziness.
  • Feeling tired or weak.
  • Stomach pain.
  • Headache.
  • A skin lump or growth.
  • Change in eyesight, eye pain, or very bad eye irritation.
  • Loss of eyesight.
  • Seeing halos or bright colors around lights.
  • Fever or chills.
  • Sunburn.
  • Skin irritation.
  • Bumps, thick, dry, or wrinkled skin.
  • Red, painful, or itchy skin that is hot to touch.
  • Have your skin checked. Tell your doctor if you have any skin changes like a new wart, skin sore or reddish bump that bleeds or does not heal, or a change in the color or size of a mole.

Before taking this medicine

You should not use Cotellic 20 mg if you are allergic to cobimetinib.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

  • Heart disease, heart rhythm disorder
  • A History of eye problems (especially a problem with your retina);
  • Liver or kidney disease
  • Skin problems not related to Melanoma
  • A muscle disorder.
  • A Bleeding or blood clotting disorder such as hemophilia
  • A Condition for which you take a blood thinner such as warfarin (Coumadin, Jantoven).

May harm an unborn baby. Do not use if you are pregnant. Secondly  Cotellic 20 mg price Use effective birth control while using Cotellic 20 mg and for at least 2 weeks after your last dose. Tell your doctor if you become pregnant.

Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose.

Also, Cobimetinib may affect fertility in men or women. Pregnancy could be harder to achieve while either parent is using this medicine.

Cotellic 20 mg side effects

Get emergency medical help if you have signs of an allergic reaction to Cotellic: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Cotellic 20 mg may cause serious side effects. Call your doctor at once if you have:

  • Vision Changes, Partial Vision loss, Seeing halos Around Lights.
  • Unexplained Muscle Pain, Tenderness, or Weakness
  • Easy Bruising or Bleeding
  • Signs of Bleeding Inside the body – Weakness, Dizziness, Headache, red or pink urine, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds
  • Signs of a heart problem – Cough, Wheezing, shortness of breath (even with mild exertion), chest pain, fast heartbeats, swelling in your feet or ankles
  • Low levels of Sodium in the body – Headache, Confusion, Slurred Speech, Severe Weakness, Committing, loss of Coordination, feeling unsteady
  • Liver problems – Cotellic 20 mg price Nausea, Upper Stomach pain, Tired Feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
  • Severe skin reaction – skin pain, itching, redness, bumps or pimples, thickened or wrinkled skin, skin rash that spreads and causes Blistering and peeling.

Your cancer treatments may be delay or permanently discontinued if you have certain side effects.

Common Cotellic 20 mg side effects may include:

  • Nausea, Vomiting, Diarrhea, upset stomach, heartburn.
  • Bumps similar to acne on face, scalp, chest, or upper back.
  • Dry skin, itching, rash
  • Tiredness
  • Swelling of arms, legs, or feet
  • Pain and burning when you urinate
  • Lung problems
  • Fever
  • Increased sensitivity to sunlight; or
  • Abnormal blood tests.


What class of drug is cobimetinib?

Cobimetinib is also used to treat histiocytic neoplasms (conditions that cause excessive production and accumulation of white blood cells in certain parts of the body). Cobimetinib belongs to a group of drugs called kinase inhibitors.

What is Cotellic used for?

COTELLIC belongs to a group of drugs called antineoplastic (or anticancer). COTELLIC is used to treat a type of skin cancer called melanoma that has spread to other parts of the body and cannot be removed by surgery.

What is the generic name for cotellic?

Genentech: Cotellic® (cobimetinib) - Information for Patients.

How does cobimetinib work?

Cobimetinib is used in patients whose cancer has a mutated (changed) form of a gene called BRAF. It is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps slow or stop the spread of cancer cells.

How do I store and/or throw out Cotellic?

  • Store at room temperature.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Cobimetinib price Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use and disclaimer

  • Firstly Cotellic 20 mg price If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else’s drugs.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. Because if you have any questions about Cotellic, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happen.
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