Caprelsa Vandetanib 300 mg price/ Cost Check online best online at Yourmedikart, and is a targeted cancer therapy used to treat a rare type of thyroid cancer. Caprelsa Vandetanib cost is best online and it works by interfering with cancer cell growth and the spread of malignant cells throughout the body.

• Generic Name: Vandetanib
• Brand Name: Caprelsa
• Drug Class: Antineoplastics EGFR Inhibitors, Antineoplastic Tyrosine Kinase Inhibitors

What is Caprelsa?

Caprelsa (generic name: Vandetanib) is a targeted therapy used in the treatment of a specific type of thyroid cancer. It is an oral medication that belongs to a class of drugs known as tyrosine kinase inhibitors (TKIs). These medications work by interfering with the growth and spread of cancer cells in the body by blocking key enzymes involved in cellular signaling pathways.

Caprelsa is specifically indicated for the treatment of symptomatic or progressive medullary thyroid cancer (MTC) in adults who have unresectable locally advanced or metastatic disease. It is not approved for use in patients with other types of thyroid cancer, such as differentiated or anaplastic thyroid cancer.

Special Distribution Program

Vandetanib price is available only through a restricted distribution program known as the Caprelsa REMS Program (Risk Evaluation and Mitigation Strategy). This program ensures that prescribers and patients are aware of and comply with safety guidelines due to the risk of potentially life-threatening heart rhythm problems associated with the drug. Patients must be enrolled in the program to receive Caprelsa.

How Caprelsa Works (Mechanism of Action)

Vandetanib, the active ingredient in Caprelsa, works by inhibiting several proteins that promote cancer cell survival and blood vessel formation:

• VEGFR (Vascular Endothelial Growth Factor Receptor) – involved in angiogenesis (the development of new blood vessels that supply tumors).

• EGFR (Epidermal Growth Factor Receptor) – supports cell growth and survival.

• RET (Rearranged during Transfection) – a proto-oncogene often mutated in medullary thyroid cancer.

By blocking these receptors, Vandetanib price disrupts the communication between cancer cells and their environment, thereby slowing or stopping tumor growth and reducing its blood supply.

Important Safety Warnings

Pregnancy and Breastfeeding

• Pregnancy Risk: Caprelsa can cause harm to an unborn baby. Women who are pregnant or may become pregnant must not use the drug. Effective birth control should be used during treatment and for at least 4 months after the last dose.

• Breastfeeding: Do not breastfeed while on Caprelsa and for at least 4 months after stopping the medication. It is unknown whether Vandetanib price passes into breast milk, but due to potential risks to the infant, breastfeeding is contraindicated.

Heart Risks

• Caprelsa can cause QT prolongation, a potentially fatal heart rhythm condition. An ECG should done before starting the drug and periodically thereafter.

• Do not use if you have:

  • Congenital long QT syndrome

  • Uncontrolled electrolyte imbalances (low calcium, magnesium, potassium)

  • A history of serious heart rhythm disturbances

• Contact your doctor immediately if you experience:

  • Palpitations

  • Sudden dizziness

  • Fainting

  • Irregular heartbeat

Other Medical Warnings

• Caprelsa may affect liver, kidney, or thyroid function, and delay wound healing. It should use cautiously in patients undergoing surgery or with underlying chronic conditions.

Before Taking Caprelsa 300 mg

Inform your doctor if you have or have ever had:

• Heart conditions, high blood pressure, or arrhythmia

• Electrolyte abnormalities

• Liver or kidney disease

• Lung problems (e.g., dry cough, shortness of breath, or coughing up blood)

• Seizures or brain-related disorders

• Skin conditions or sensitivity

• Chronic diarrhea or gastrointestinal issues

Also tell your doctor about:

• All prescription and OTC medications

• Any supplements, herbal remedies, or vitamins

• Recent or planned surgeries (Caprelsa may need to be temporarily discontinued)

How to Take Caprelsa 300 mg

• Dosage: The standard adult dose is 300 mg orally once daily.

• Administration: Take Caprelsa with a full glass of water, with or without food.

  • Swallow tablets whole—do not crush, chew, or break.

  • If you cannot swallow the tablet, you may disperse it in 2 oz (60 mL) of non-carbonated water, stir well, and drink immediately. Rinse the glass with 4 oz (120 mL) of water and drink that too.

• Feeding tube: This mixture may also be given through a nasogastric (NG) or gastrostomy (G) tube under medical supervision.

Missed Dose

If a dose is miss and the next scheduled dose is more than 12 hours away, take the miss dose as soon as possible. If less than 12 hours remain, skip the missed dose. Do not double the dose.

Overdose

If you suspect an overdose, contact your local poison control center or emergency services. Symptoms may include severe heart rhythm issues, fainting, or seizures.

Monitoring During Treatment

• ECGs (Electrocardiograms): Baseline and regular ECGs every 2–12 weeks to monitor heart rhythm

• Blood Tests: Periodic monitoring of electrolytes, liver/kidney function, and thyroid hormone levels

• Imaging: Scans to track tumor response and progression

Drug and Food Interactions

Drug Interactions

Caprelsa can interact with many medications, especially those that:

• Prolong the QT interval (e.g., certain antipsychotics, macrolide antibiotics, and antiarrhythmic drugs)

• Affect liver enzymes (e.g., CYP3A4 inhibitors like ketoconazole or inducers like rifampin)

Avoid:

• St. John’s Wort – Can reduce effectiveness of Caprelsa

• Other QT-prolonging drugs unless deemed absolutely necessary

Always provide your doctor with a complete list of everything you take.

Food and Alcohol

• No known food interactions but avoid alcohol which may worsen fatigue and other side effects.

• Limit sun exposure – Vandetanib price can increase photosensitivity and risk of severe sunburns. Use sunscreen and protective clothing.

Side Effects of Caprelsa

Common Side Effects

• High blood pressure

• Diarrhea, abdominal pain

• Nausea, vomiting, loss of appetite

• Acne, skin rashes

• Tiredness, headache

• Cold-like symptoms (sore throat, congestion)

Serious Side Effects – Seek Immediate Medical Help

• Signs of heart rhythm problems (fast, irregular heartbeat, fainting)

• Stroke-like symptoms (numbness, confusion, vision trouble)

• Persistent severe diarrhea

• Bleeding or bruising easily

• Seizures, confusion, or altered mental status

• Thyroid dysfunction

• Pulmonary symptoms – wheezing, coughing blood

• Severe skin reactions – painful rash, blistering, or peeling skin

Storage Instructions

• Store Caprelsa 300 mg tablets at room temperature (20–25°C or 68–77°F)

• Keep the container tightly closed, away from moisture and direct heat

• Do not use broken tablets; they can be hazardous upon contact. If a tablet breaks, wash skin with soap and water or flush eyes if exposed

Caprelsa 300 mg Use in India

In India, Caprelsa 300 mg may be available through special importation due to its limited availability and regulation. Patients often receive it through specialized pharmacies or under oncologist supervision. Due to high cost, Vandetanib price some patients explore patient assistance programs or international procurement via licensed vendors.