Clexane Inj

 330.00 500.00








Clexane is basically the brand name for Enoxaparin sodium, which is basically an anticoagulant (blood thinner). It serves the purpose of reducing coagulation of blood, prolonging the clotting time. In layman’s terms, Clexane is used for stopping the blood clots to form within the blood vessels. Clexane is used to serve a few major purposes. From treating blood clots to treating for heart borne diseases like heart attack to also coming handy after surgeries, mainly in avoiding blood clot formation, clexane has it’s own purpose to fulfill.

Who Is It For

There are a few categories which should refrain from using Clexane. Some of them are :-

* Kids / People under the age of 18
* People over the age of 80
* People who have recently undergone a surgery
* Diabetic patients
* Patients with a history of blood disorders
* Patients who have troubles stopping bleeding
* People who are significantly underweight or overweight
* People with kidney troubles
* People with decreased liver function
* Hyperkalemics
* Pregnant or breastfeeding ladies

Drug Administration

Clexane is administered by injection under the skin of the abdomen or into the tubing of dialysis machine once a day. Depending on the condition of the patient and relevant vitals such as weight, the amount of dosage is derived. The usual dosage method is simple, for patients who are moderately at risk, 20mg is provided once a day. For the high risk patients, 40mg is provided. It must be noted that it is essential to have regular blood tests during this treatment in order to regularly monitor the vitals of the patient. In case the treatment lasts for more than 7 days, the health care provider may also keep a tab on the potassium levels in the patient’s blood.

Side Effects

Like every pharmaceutical drug, Clexane comes with it’s fair share of side effects. Since it focuses on treating serious conditions, it also makes the body vulnerable. Some of the major side effects include :-

* Bleeding from gums
* Nosebleeds
* Coughing or vomiting blood
* Pain/irritation in the injected area
* Haematoma – blood clots forming a solid swelling in the injected area
* Decrease in platelet count
* Haemorrhage
* Necrosis in the area injected
* Hyperkalaemia
* Blood Clots in the spinal cord

Basic Do’s and Don’ts

There are some self care and precaution tips that everyone can and must follow.

* This one goes without saying, but one must use Clexane only under the guidance of a health care professional, and the dosage must be as prescribed.
* In case the patient has an artificial heart valve, or a stent in their heart, the health care professional must be informed about it
* If the patient is to start any new medicine, the doctor must be informed and consulted with.
* If a lady becomes pregnant while using clexane, the doctor must be informed and appropriate actions must be taken.
* The doctor must be informed about any allergic reactions, especially to Heparin.
* One must not give Clexane to anyone else, even if the other person has the same disorder. Clexane must only be prescribed by a certified doctor.
* Thorough consultation is suggested for patients who’re using Clexane.
* One must not self regulate the dosage, or the time gap between dosages.
* Clexane must not be mixed or used with any other drug or injection, unless it’s prescribed that way.
* Any complication must be discussed with the doctor as soon as it is identified.
* Clexane must not be injected into the muscle.

Clexane is available in a few forms to pick from, like, injection, prefilled syringes and graduated prefilled syringes. We at Your Medikart understand that people with different needs must get different options to choose from. Our certified partners ensure that the prescribed drug you require reaches your doorstep without any hindrance.

Clexane (enoxaparin)

Clexane injection contains the active ingredient enoxaparin, which is a type of medicine called a low molecular weight heparin. It is used to stop blood clots forming within the blood vessels.

What is Clexane used for?

  • Treating blood clots in the veins of the leg (deep vein thrombosis).
  • Treating blood clots in the lungs (pulmonary embolism).
  • Preventing these types of blood clots (thromboembolic disorders), particularly following general surgery or surgery on the bones (orthopaedic surgery), or in people bedridden due to illness.
  • Treating blood clots in the coronary arteries in unstable angina and heart attack (myocardial infarction).
  • Preventing blood from clotting when it is filtered through an ‘artificial kidney’ (haemodialysis) machine as part of the management of kidney failure.

How does Clexane work?

Clexane injection contains the active ingredient enoxaparin, which is a type of medicine called a low molecular weight heparin. It stops blood clots forming inside the blood vessels.

Blood clots normally only form to stop bleeding that has occurred as a result of injury to the tissues. The clotting process is complicated and begins when blood cells called platelets clump together and produce chemicals that activate the clotting process. The final part of this process involves a substance called thrombin being activated to produce a protein called fibrin. Fibrin binds the platelets together, forming a blood clot. This is the body’s natural way of repairing itself.

Sometimes, however, a blood clot can form abnormally within the blood vessels. This is known as a thrombus. It can be dangerous because the clot may detach and travel in the bloodstream, where it becomes known as an embolus. The embolus may eventually get lodged in a blood vessel, thereby blocking the blood supply to a vital organ such as the heart, brain or lungs. This is known as a thromboembolism.

Some people have an increased tendency for blood clots to form within the blood vessels. This is usually due to a disturbance in the blood flow within the blood vessels. For example, in coronary artery disease, fatty deposits (atherosclerosis) on the walls of the coronary arteries can disrupt the blood flow, giving a tendency for platelets to clump together and start off the clotting process. When a clot has formed in a coronary artery this reduces the flow of blood to the heart and causes chest pain (angina). It can also result in a heart attack.

Slow blood flow in the leg and pelvic veins can also result in clots forming in these veins (deep vein thrombosis). These clots can break off and travel to the lungs (pulmonary embolism). Being immobile for long periods of time, for example due to a severe medical condition or following surgery, can increase the risk of these types of blood clot, as can pregnancy, obesity and certain blood disorders.

Enoxaparin can prevent and treat these types of abnormal blood clots. It works by inactivating thrombin in the clotting process described above. This stops the formation of fibrin, the essential component of blood clots.

How is Clexane given?

  • Clexane is administered by injection under the skin of the abdomen (subcutaneous injection).
  • The dose and length of treatment used will depend on the nature of the clot being treated or prevented.

Important information about Clexane

  • During treatment with this medicine you may need to have regular blood tests to monitor the numbers of blood cells called platelets in your blood.
  • Your doctor may also want to monitor the level of potassium in your blood while you are having this medicine, particularly if treatment lasts for longer than seven days.

Clexane should be used with caution in

  • People over 80 years of age.
  • People who are underweight or overweight.
  • People with decreased kidney function or chronic kidney failure.
  • People with decreased liver function.
  • People who have previously developed a reduced platelet count in the blood due to treatment with heparin or low molecular weight heparin (heparin-associated thrombocytopenia).
  • People with problems stopping bleeding.
  • People with a history of peptic ulcer.
  • People who have recently had a stroke caused by a blood clot in the brain (ischaemic stroke).
  • Severe uncontrolled high blood pressure (hypertension).
  • Diabetes.
  • People with diabetes affecting the eyes (diabetic retinopathy).
  • People who have recently had eye surgery.
  • People who have recently had surgery on the brain or spinal cord (neurosurgery).
  • People having spinal or epidural anaesthesia.
  • People with a high level of potassium in their blood (hyperkalaemia).
  • People with increased acidity in their blood (metabolic acidosis).

Clexane should not be used in

  • People who are allergic to heparin or other low molecular weight heparins.
  • People with a bacterial infection of the heart valves and the lining surrounding the heart (bacterial endocarditis).
  • People with active major bleeding.
  • People with conditions that carry a high risk of uncontrolled bleeding, for example the blood clotting disorder haemophilia, a peptic ulcer, a recent stroke caused by bleeding in the brain (haemorrhagic stroke) or a reduced platelet count in the blood (thrombocytopenia).
  • This medicine is not recommended for use in children.
  • This medicine is not recommended for preventing blood clots in people with an artificial heart valve.

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

  • This medicine is not licensed for use during pregnancy. However, the medicine does not cross the placenta and so does not enter the baby’s bloodstream. It is not known to be harmful if used during pregnancy. Low molecular weight heparins such as this one are often used to prevent and treat blood clots in pregnant women. However, the medicine is not recommended for preventing blood clots in pregnant women with artificial heart valves, because there is insufficient information regarding its use in this particular case. Seek further medical advice from your doctor.
  • This medicine has not been studied in women who are breastfeeding. However, it is unlikely to pass into breast milk and even if it did, it would be inactivated in the gut of the baby. The medicine is not expected to be harmful to a nursing infant if it is used to treat mothers who are breastfeeding. Seek further medical advice from your doctor.

Possible side effects of Clexane

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.

  • Bleeding. It is important to tell your doctor straight away if you notice any signs of bleeding while you are receiving treatment with this medicine, for example nosebleeds, bruising, coughing up or vomiting blood, blood in your urine, or black, tarry or bloodstained stools.
  • Pain and irritation at the injection site.
  • Blood clots which form a solid swelling at the injection site (haematoma).
  • Decrease in the number of platelets in the blood (thrombocytopenia).
  • Major bleeding (haemorrhage), for example in the abdomen or inside the skull.
  • Alteration in results of liver function tests.
  • Raised blood potassium level (hyperkalaemia).
  • Death of skin cells (necrosis) at the site of injection.
  • Blood clots in the spinal cord (intraspinal haematoma) in people also having spinal or epidural anaesthesia.
  • Osteoporosis (a reduction in bone density leading to bones which may fracture easily) has occurred after long-term treatment with a similar medicine called heparin. Although this has not been observed in people treated with Clexane, it is possible that this could happen with Clexane.

The side effects listed above may not include all of the side effects reported by the medicine’s manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

If you think you have experienced a side effect from a medicine or vaccine you should check the patient information leaflet. This lists the known side effects and what to do if you get them. You can also get advice from your doctor, nurse or pharmacist. If they think it’s necessary they’ll report it for you.

Can I use other medicines with Clexane?

It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while having treatment with this one, to make sure that the combination is safe.

There may be an increased risk of bleeding or increased time taken to stop bleeding, if this medicine is used in combination with medicines that affect blood clotting, such as the following:

  • antiplatelet (‘blood-thinning’) medicines, such as aspirin, dipyridamole, clopidogrel
  • clot-busting medicines (fibrinolytics) such as streptokinase, alteplase
  • dextran
  • iloprost
  • non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, diclofenac, naproxen (do not take this type of painkiller while you are having treatment with this medicine unless you have discussed it with a doctor or pharmacist first)
  • oral anticoagulants, such as warfarin, nicoumalone, phenindione, dabigatran, rivaroxaban, apixaban.

There may be an increased risk of a rise in the amount of potassium in your blood if this medicine is used in combination with any of the following:

  • ACE inhibitors, eg captopril, lisinopril
  • aliskiren
  • ciclosporin
  • potassium-sparing diuretics, eg spironolactone, triamterene, amiloride
  • potassium supplements
  • potassium-containing salt substitutes.

The amount of potassium in your blood should be regularly monitored if you are taking any of these during treatment with this medicine.

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