CIPLA ONCO CARE
PACKING : 1X120
GENERIC NAME : ABIRATERONE ACETATE
What is Xbira ?
XBIRA 250mg – Abiraterone Acetate is a drug used in combination with prednisone in metastatic castration-resistant prostate cancer (formerly hormone-resistant prostate cancer) which is a prostate cancer not responding to androgen deprivation or treatment with anti-androgens. XBIRA is a CYP17 inhibitor indicated in combination with prednisone for the treatment of patients with metastatic CRPC who have received prior chemotherapy containing docetaxel.
XBIRA (abiraterone acetic acid derivation) tablets are demonstrated in blend with prednisone for the treatment of patients with metastatic CRPC who have received earlier chemotherapy containing docetaxel.
The suggested dose of XBIRA tablets is 1,000 mg (four 250 mg tablets) regulated orally once-day by day in blend with prednisone 5 mg directed orally twice-every day. XBIRA tablets must be taken on an empty stomach. No food ought to be burned-through for in any event 2 hours before the dose of XBIRA tablet is taken and for at any rate 1 hour after the dose of XBIRA tablet is taken.
How it works ?
Abiraterone Acetate decreased serum testosterone and other androgens in patients in the placebo-controlled Phase 3 clinical trials. It is not necessary to monitor the effect on serum testosterone levels.
Changes in serum prostate-specific antigen (PSA) levels may be observed, but have not been shown to correlate with clinical benefit in individual patients.Abiraterone Inhibits 17 Α-Hydroxylase/C17,20 Lyase (CYP17A1), An Enzyme Which Is Expressed In Testicular, Adrenal, And Prostatic Tumor Tissues. CYP17 Catalyzes Two Sequential Reactions: (A) The Conversion Of Pregnenolone And Progesterone To Their 17-Α-Hydroxy Derivatives By Its 17 Α-Hydroxylase Activity, And (B) The Subsequent Formation Of Dehydroepiandrosterone (DHEA) And Androstenedione, Respectively, By Its C17,20 Lyase Activity. DHEA And Androstenedione Are Androgens And Precursors Of Testosterone. Inhibition Of CYP17 Activity By Abiraterone Thus Decreases Circulating Levels Of Testosterone.
What is abiraterone acetate used for?
Abiraterone is used in blend with prednisone to treat a particular type of prostate cancer that has spread to different parts of the body. Abiraterone is in a class of prescriptions called androgen biosynthesis inhibitors. It works by diminishing the measure of specific hormones in the body.
Is abiraterone a chemotherapy drug?
Abiraterone is a hormone treatment drug. It is a therapy for prostate cancer. You may have abiraterone: if other hormone medicines are done working, and you have no or mild symptoms except for you needn't bother with chemotherapy.
How does abiraterone acetate work?
Abiraterone works by Stopping the body creating a hormone called testosterone. It does this in an alternate manner to different type of hormone treatment. In most men, prostate cancer cells can't develop without testosterone, regardless of whether they have spread to different parts of the body.
What happens when abiraterone stops working?
At the point when Taxotere stops working, other chemo drugs, for example, Jevtana (cabazitaxel), can help extend survival in certain men. Possible side effects of Taxotere include sickness, balding, and diminished creation of platelets. Men may also create liquid maintenance and pain, shivering, or numbness in the fingers or toes.
What are the side effects of abiraterone?
The most widely recognized side effects of abiraterone include: Feeling very tired. Joint pain. Hypertension. Sickness. Swelling in your legs or feet. Low blood potassium levels. Hot flushes. Diarrhea.
Is abiraterone acetate a steroid?
Abiraterone acetate, sold under the brand name Zytiga among others, is a medicine used to treat prostate cancer. Explicitly it is utilized along with a corticosteroid for metastatic castration-resistant prostate cancer (mCRPC) and metastatic high-risk castration-sensitive prostate cancer (mCSPC).
How to take it’s dosage?
The recommended dose of these tablets is 1000mg (four 250mg tablets) administered orally once daily in combination with Prednisone 5mg administered orally twice daily. Tablets must be taken on an empty stomach. No food should be consumed for at least 2 hours before the dose of tablets is taken and for at least 1 hour after the dose of XBIRA tablets is taken. The tablets should be swallowed whole with water and not to be crushed or chewed.
Abiraterone acetic acid derivation must be taken on an empty stomach. No food ought to be burned-through for at any rate 2 hours before the dose of abiraterone acetic acid derivation is taken and for in any event 1 hour after the portion of abiraterone acetic acid derivation is taken. Abiraterone Cmax and AUC0-∞ (presentation) were expanded up to 17-and 10-crease higher, individually, when a single dose of abiraterone acetic acid derivation was managed with a feast contrasted with an abstained state. The safety of these expanded presentations when different dosages of abiraterone acetic acid derivation are taken with food has not been assessed.
Prominent side effects .
- Fluid Retention (Edema)
- Urinary tract infection
- Joint swelling
- Increased liver enzymes
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