Vaccines are treat leukemia when other drugs do not show much progress. It stops the growth of cancer, helps it to spread, and reduces the symptoms of breast cancer (such as breast cancer, bleeding lips, or changes in image or location) . In the heart. This injection given by healthcare professional. For best results, in other words  sure to follow your doctor’s instructions. for instance Call now for Perjeta Pertuzumab Injection 420Mg price in India, Product by ROCHE

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GENERIC NAME : PERTUZUMAB

Perjeta 420 mg

What is Perjeta ?

Pertuzumab Pertuzumab Injection 420mg Injection (chemical name: Pertuzumab), used with Herceptin (chemical name: trastuzumab), another targeted drug, Texture (chemical name: docetaxel), a type of chemotherapy for the treatment of metastatic cancer HER2 -positive, Herceptin has not used treated by chemotherapy.

previous browser called Perjeta  Pertuzumab 420mg Injection Omnitarg.

Perjeta Pertuzumab 420mg Injection used to treat breast cancer. It has a place with group of medication called monoclonal antibodies.

Pertuzumab 420 mg given under Guidance. Most Importantly Your doctor will determine how much you need and how much you should take. This depends on the purpose of the treatment and may change over time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking an excessive amount can cause serious side effects. It may take a few months for you to see the benefits, but don’t stop taking it unless your doctor advises you. in other words

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It has a place with group of medication called monoclonal antibodies. Perjeta 420mg price in india is Bargain. in  Pertuzumab Cost in India is bargain. Pertuzumab Cost  in india is Best. and  Injection used treat breast cancer. It has a place with group of medication called monoclonal antibodies. Perjeta Pertuzumab 420mg Injection 420mg price in india is good at Yourmedikart.

Many other medicines can influence, influenced by, this medication so let your medical care team know all meds you are using. During pregnancy or breastfeeding medication not advice. The use of powerful contraception by both males and females during treatment is essential to stay away from pregnancy. Perjeta 420mg price in india is best.

Vaccines used to treat leukemia when other drugs not work. It stops the growth of cancer, helps it to spread, and reduces the symptoms of breast cancer (such as breast cancer, bleeding lips, or changes in image or location) . In the heart. This medication is injection by a specialist or healthcare professional. For best results, be sure to follow your doctor’s instructions. Follow your doctor’s instructions cautiously to get the most advantage.

Perjeta 420 mg

Perjeta also is approved:

for use in combination with Herceptin and Texture before surgery to treat HER2-positive breast cancer, early stage (cancer must be larger than 2 cm or cancer must be in the lymph nodes), inflammatory or locally advanced with a high risk of metastasis or becoming fatal
to be used in combination with Herceptin and chemotherapy after surgery to treat early stage HER2-positive breast cancer at high risk of recurrence

How Pertuzumab 420mg Injection Works

Perjeta 420 mg injection is monoclonal anti-cancer drug to detect and bind proteins on top of cancer cells. The virus linked to growth of type 2 (HER2) in young cells and can kill or stop the growth of cancer cells.

When to contact your doctor or health care provider:

Contact your health care provider immediately, day or night or go to the emergency room, if you should experience any of the following symptoms:

  • Fever of 100.4º F (38º C) or higher, chills (possible signs of infection)
  • Signs of a reaction (wheezing; chest tightness; fever; itching; bad cough; blue or grey skin color; seizures; swelling of the face, lips tongue or throat)
  • Trouble breathing
  • Chest pain or pressure or a fast heartbeat

The following symptoms require medical attention, but are not an emergency. Contact your health care provider within 24 hours of noticing any of the following:

  • Signs of infection: Fever, chills, very bad sore throat, ear or sinus pain, cough with or without sputum, pain with passing urine, wounds that will not heal
  • Nausea (interferes with ability to eat and unrelieved with prescribed medication)
  • Vomiting (vomiting more than 4-5 times in a 24 hour period)
  • Diarrhea (4-6 episodes in a 24-hour period)
  • Dizziness or lightheadedness
  • Bad headache
  • Big weight gain
  • Unusual bleeding or bruising
  • Extreme fatigue (unable to carry on self-care activities)
  • Muscle weakness
  • Mouth sores (painful redness, swelling or ulcers)

Always inform your health care provider if you experience any unusual symptoms.

Precautions:

  • Before starting Perjeta™ treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.).
  • Do not receive any kind of immunization or vaccination without your doctor’s approval while taking Perjeta™.
  • Inform your health care professional if you are pregnant or may be pregnant prior to starting this treatment. Pregnancy category D (Perjeta™ may be hazardous to the fetus. Women who are pregnant or become pregnant must be advised of the potential hazard to the fetus.)
  • For both men and women: Use contraceptives, and do not conceive a child (get pregnant) while taking Perjeta™. Barrier methods of contraception, such as condoms, are recommended. Verify pregnancy status prior to treatment initiation. Effective contraception should be used during therapy and for 6 months after treatment.
  • Do not breast feed while taking Perjeta™.

Self-Care Tips:

  • Drink at least two to three quarts of fluid every 24 hours, unless you are instructed otherwise.
  • You may be at risk of infection so try to avoid crowds or people with colds, and report fever or any other signs of infection immediately to your health care provider.
  • Wash your hands often.
  • To help treat/prevent mouth sores, use a soft toothbrush, and rinse three times a day with 1 teaspoon of baking soda mixed with 8 ounces of water.
  • Use an electric razor and a soft toothbrush to minimize bleeding.
  • Avoid contact sports or activities that could cause injury.
  • To reduce nausea, take anti-nausea medications as prescribed by your doctor, and eat small, frequent meals.
  • Follow regimen of anti-diarrhea medication as prescribed by your health care professional.
  • Eat foods that may help reduce diarrhea (see managing side effects – diarrhea).
  • Acetaminophen or ibuprofen may help relieve discomfort from fever, headache and/or generalized aches and pains. However, be sure to talk with your doctor before taking it.
  • Avoid sun exposure. Wear SPF 15 (or higher) sun block and protective clothing.
  • In general, drinking alcoholic beverages should be kept to a minimum or avoided completely. You should discuss this with your doctor.
  • Get plenty of rest.
  • Maintain good nutrition.
  • Remain active as you are able. Gentle exercise is encouraged such as a daily walk.
  • If you experience symptoms or side effects, be sure to discuss them with your health care team. They can prescribe medications and/or offer other suggestions that are effective in managing such problems.

Monitoring and Testing:

  • Lab work to check blood counts and liver/kidney functions will be checked regularly by your health care professional while you are taking Perjeta, to monitor side effects and check your response to therapy.
  • HER2 expression must be present for initiation of Perjeta.
  • Negative pregnancy test prior to initiation.
  • Cardiac studies to assess Left Ventricular Ejection Fracture (LVEF), may be ordered.

How Perjeta Works:

Targeted therapy is the result of about 100 years of research dedicated to understanding the differences between cancer cells and normal cells. To date, cancer treatment has focused primarily on killing rapidly dividing cells because one feature of cancer cells is that they divide rapidly. Unfortunately, some of our normal cells divide rapidly too, causing multiple side effects.

Targeted therapy is about identifying other features of cancer cells. Scientists look for specific differences in the cancer cells and the normal cells. This information is used to create a targeted therapy to attack the cancer cells without damaging the normal cells, thus leading to fewer side effects. Each type of targeted therapy works a little bit differently but all interfere with the ability of the cancer cell to grow, divide, repair and/or communicate with other cells.

There are different types of targeted therapies, defined in three broad categories. Some targeted therapies focus on the internal components and function of the cancer cell. The targeted therapies use small molecules that can get into the cell and disrupt the function of the cells, causing them to die. There are several types of targeted therapy that focus on the inner parts of the cells. Other targeted therapies target receptors that are on the outside of the cell. Therapies that target receptors are also known as monoclonal antibodies. Antiangiogenesis inhibitors target the blood vessels that supply oxygen to the cells, ultimately causing the cells to starve.

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Perjeta has the component of an antibody type of targeted therapy. Antibodies are an integral part of the body’s immune system. Normally the body creates antibodies in response to an antigen (such as a protein or a germ) that has entered the body. The antibodies attach to the antigen in order to mark it for destruction by the immune system.

To make anti-cancer antibodies in the laboratory, scientists analyze specific antigens on the surface of cancer cells (the targets). Then using animal and human proteins, they create a specific antibody that will attach to the target antigen on the cancer cells. When given to a patient, these antibodies will attach to matching antigens like a key fits a lock. Since antibodies target only specific cells, they may cause less toxicity to healthy cells. Monoclonal antibody therapy is usually only given for cancers in which antigens and the respective antibodies have been identified already.

Dosage

Recommend Doses And Schedules

The initial dose of PERJETA is 840 mg by intravenous injection within 60 minutes, followed by 420 mg injection every three weeks for more than 30 to 60 minutes.

When administered with PERJETA, the recommend dose of trastuzumab was 8 mg / kg by injection within 90 minutes, followed by 6 mg / kg by intravenous injection within 30 to 90 minutes every three weeks.

PERJETA, trastuzumab and tachycardia should used sequentially. PERJETA and trastuzumab can given in any form. Taxane should given after PERJETA and trastuzumab. A screening time of 30 to 60 minutes is recommend after PERJETA infusion and before starting trastuzumab or any subsequent taxed infusions.

In patients receiving an anthracycline-based regimen, PERJETA and trastuzumab should administered after completion of the anthracycline treatment.

Patient Selection

Select patients based on HER2 protein overexpression or HER2 gene amplification in tumor samples [see INDICATIONS and Clinical Studies]. Evaluation of HER2 protein overexpression and HER2 gene amplification should performed using FDA-approved tests specific for breast cancer by laboratories with demonstrated competence. Information on FDA-approved tests for the detection of HER2

Inadequate assay performance, including use of suboptimal fixed tissue, failure to use specific reagents, deviation from specific assay instructions, and failure to include appropriate controls for assay validation may result in to unreliable results.

Therapeutic Indications

Early breast cancer

Pertuzumab 420mg Injection is shown for use in combination with trastuzumab and chemotherapy in:

• the neoadjuvant therapy of adult patients with HER2-positive, privately progressed, inflammatory, or early stage breast cancer at high risk of recurrence.

• the adjuvant therapy of adult patients with HER2-positive early breast cancer at high risk of recurrence.

Metastatic breast cancer

Pertuzumab 420 mg injection with trastuzumab and docetaxel is recommend for adults with HER2-elevated untreated breast cancer those have not yet received HER2 treatment or medication for metastatic disease.

Perjeta 420mg price in India is bargain. Perjeta Injection price best in India used treat breast cancer. place with group of medication called monoclonal antibodies. Cost of Perjeta Steal in India

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How Perjeta works

Cancer cells grow out of control. Perjeta works on cancer cells by blocking chemical signaling that can lead to uncontrolled growth.

Genetics is like a guidebook that tells every cell in our body how to grow, what kind of cell it will become, and how to behave. Genetics does this by telling the cell to produce a special protein that activates a specific function, such as growing cells, resting, or repairing it.

Some cancer cells have abnormalities in the genes that tell them. For instance, How many cells there are and how fast they can grow. Sometimes cancer cells have many of these defective genes.

in other words When there are too many of these genes, doctors talk about “extreme expression”. With some form of genetic hyperplasia, cancer cells will produce many proteins that regulate cell growth and division, causing cancer cells to grow and spread.

What to expect when taking Perjeta ?

Perjeta was prescribe with Herceptin and chemotherapy. these drugs are given by intravenous injection. That is, it enters the bloodstream directly through the IV or port.

The first dose of Perjeta was the biggest and lasted about an hour. After that, it takes 30 to 60 minutes, and you are given Perjeta, usually given at your doctor’s office once every three weeks. Most people receive Perjeta every 3 weeks for 18-25 months.

Perjeta not give to women who are pregnant or planning to become pregnant. Perjeta can cause embryonic death and miscarriage. It is important to avoid pregnancy while taking Perjeta. You need to use good prevention.

What to expect when taking Perjeta and what is Perjeta 420 mg price in india

Perjeta is prescribe with Herceptin and chemotherapy. which means they are administered directly into the bloodstream through a drip or port.

The first dose of Perjeta is the largest and takes about an hour to complete. After that takes 30 to 60 minutes to get Perjeta usually given every 3 weeks in a doctor’s office. Most people take Perjeta every 3 weeks for 18-25 months. Women who are pregnant or planning to become pregnant should not receive Perjeta. Perjeta can cause embryonic death and birth defects. It is important that you do not get pregnant while taking Perjeta; An effective method of contraception must be used.

How to use Perjeta 420mg injection

Perjeta injection 420mg is given in every 3 weeks. You should let your doctor know if the medicine stops. After the expiration date, the drug should not used. perjeta 420mg price in india The drug not used when there are foreign particles and any color change.

Safety Information

Breastfeeding: Consult your physician whether to breastfeed during this medication.

Pregnancy:

Perjeta 420mg injection can cause harm to the unborn child when administered to pregnant women.

Allergy:

Perjeta 420mg injection has a minor effect in the case of driving.

Driving:

Perjeta 420mg injection has a minor effect in the case of driving.

Warnings/Precautions:

Risk of left ventricular dysfunction. Check left ventricular ejection fraction (LVEF) before treatment and during interim treatment (eg, every 12 weeks for MBC or EBC [once for neoadjuvant therapy]). Stop using Pertuzumab and trastuzumab to lower LVEF (see all packages). LVEF level ≤ 50% before treatment, history of CHF, LVEF reduced to < 50% during previous treatment with trastuzumab, uncontrolled hypertension, recent myocardial infarction, cardiac arrhythmia weight requiring treatment or doxorubicin > 360 mg/m2 Prior cumulative exposure or equivalent in: Not studied.

Monitor for signs/symptoms of infusion vaccine. Delay or stop treatment and correct it if this happens. Permanent delay in serious cases. Embryo-foetal toxicity. Pertuzumab 420mg Injection Women who could become pregnant should. Advised to use the appropriate vaccine at the last minute and for 7 months after the injection.

Perjeta side effects

Perjeta is given with Herceptin and most importantly to aware that heart disease can lead to Herceptin side effects. Although studies have shown that adding. Similarly Perjeta to Herceptin does not increase the risk of heart disease. Moreover, your doctor may wish to test your heart function before and during treatment with Perjeta, Herceptin and chemotherapy. Perjeta 420mg price in india. Pertuzumab 420mg Injection

The most common side effects of Perjeta are:

diarrhea
hair loss
thirdly Low white blood cell count (neutropenia)
crowd
weak
red rash
Peripheral neuropathy for Instance, tingling. Or burning of the hands and feet above all are common side effects

When to contact your doctor or health care provider:

See your doctor right away, day or night, or go to the emergency room. If you experience any of the following symptoms:

  • Fever of 100.4º F (38º C) or higher, chills (possible signs of infection)
  • So Signs of a reaction (wheezing, chest tightness, fever, itching, bad cough, blue or gray skin color, seizures,
  • Swelling of the face, lips, tongue or throat)
  • Thirdly Difficult breathing
  • Most Importantly Chest pain or pressure, or a rapid heartbeat
    In Addition The following symptoms require medical attention but are not an emergency. Pertuzumab 420mg Injection Contact your doctor within 24 hours of noticing any of the following:

    • Firstly Signs of infection: fever, chills, severe sore throat. Ear or sinus pain, cough with or without sputum, painful urination, wounds that do not heal
    • Nausea (interferes with the ability to eat and is not relieved by prescribed medications)
      Vomiting (vomiting more than 4-5 times in a 24 hour period)
    • Diarrhea (4-6 episodes over a 24 hour period)
    • Dizziness or lightheadedness
    • Terrible headache
    • great weight gain
    • Unusual bleeding or bruising
    • Extreme fatigue (inability to carry out self-care activities)
    • Muscle weakness
    • Mouth sores (painful redness, swelling or ulcers)
    • Always tell your doctor if you experience any unusual symptoms. above all common effects

FAQ

Is PERJETA 420 Mg a chemotherapy drug?

Perjeta (Pertuzumab) is consider cancer therapy and different from chemotherapy. Chemotherapy works by killing fast-growing cancer cells, but it also affects normal cells. Perjeta attacks certain proteins in breast cancer cells that cause rapid growth.

What is used of PERJETA 420 Mg ?

PERJETA, together with Herceptin (trastuzumab) and docetaxel, is the first-line treatment for HER2+ breast cancer that has spread to other parts of the body (metastasis). So It will provided to you if you have not received anti-HER2 therapy or chemotherapy for metastatic breast cancer (first line).

What is PERJETA in cancer treatment?

Perjeta (chemical name: Pertuzumab) used in combination with another targeted therapy drug Herceptin (chemical name: trastuzumab) and a chemotherapy drug Texture (chemical name: docetaxel) HER2-positive metastatic breast cancer. After that He did not receive Herceptin or chemotherapy treatment.

How effective is PERJETA?

Disease-free survival rates in both groups were higher than expected: 94.1% of women in the Perjeta treatment group survived without cancer recurrence. 93.2% of women in the standard treatment group survived without cancer recurrence.

What does HER2-positive mean?

HER2 is a growth promoting protein outside of all breast cells. Breast cancer cells with higher levels of HER2 than normal are called HER2-positive. These cancers tend to grow and spread faster than other breast cancers. But are more likely to respond to drug treatments that target the HER2 protein.

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