Perjeta (pertuzumab) is a targeted therapy use in the treatment of HER2-positive breast cancer, which is a type of breast cancer characterize by excessive production of the HER2 protein. Perjeta 420mg Pertuzumab injection price in india best online at Yourmedikart.

As a monoclonal antibody, Perjeta specifically binds to the HER2 receptor on cancer cells, effectively blocking them from receiving growth signals. Vaccines are Treat Leukemia when other drugs do not show much progress.

It stops the growth of cancer, helps it to spread, and reduces the Symptoms of breast cancer. In the heart. This injection given by healthcare Professional. For best results, in other words sure to follow your doctor’s instructions. for instance, Call now for Perjeta Pertuzumab Injection 420Mg price in India, Product by ROCHE

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GENERIC NAME : PERTUZUMAB

What is Perjeta?

Perjeta also is Approved:

• Pertuzumab is intended for use in combination with Herceptin and Taxotere prior to surgery for the treatment of early-stage HER2-positive breast cancer.
• It is indicated for cases where the tumor is larger than 2 cm, or cancer is present in the lymph nodes, and in instances of inflammatory or locally advanced cancer with a high risk of metastasis or becoming fatal.
• Additionally, this medication should be used in combination with Herceptin and chemotherapy after surgery to treat early-stage HER2-positive breast cancer that has a high risk of recurrence.

How Pertuzumab 420mg Injection Works

• Pertuzumab 420mg Injection, also known as Perjeta, is a monoclonal antibody used in cancer treatment.
• It works by identifying and binding to the HER2 proteins found on the surface of cancer cells. HER2 is linked to the growth of these cells. By targeting this protein, Pertuzumab can either kill the cancer cells or halt their growth.

When to Contact your doctor or Health Care Provider:

Contact your health care provider immediately, day or night or go to the emergency room, if you should experience any of the following symptoms:

• Fever of 100.4º F (38º C) or higher, chills (possible signs of infection)
• Signs of a reaction (wheezing; chest tightness; fever; itching; bad cough; blue or grey skin color; seizures; swelling of the face, lips tongue or throat)
• Trouble breathing
• Chest pain or pressure or a fast heartbeat

The following symptoms require medical attention but are not an emergency. Contact your health care provider within 24 hours of noticing any of the following:

• Signs of infection: Fever, chills, very bad sore throat, ear or sinus pain, cough with or without sputum, pain with passing urine, wounds that will not heal
• Nausea (interferes with ability to eat and unrelieved with prescribed medication)
• Vomiting (vomiting more than 4-5 times in a 24-hour period)
• Diarrhea (4-6 episodes in a 24-hour period)
• Dizziness or lightheadedness
• Bad headache
• Big weight gain
• Unusual bleeding or bruising
• Extreme fatigue (unable to carry on self-care activities)
• Muscle weakness
• Mouth sores (painful redness, swelling or ulcers)

Always inform your health care provider if you experience any unusual Symptoms.

Precautions:

• Before starting Perjeta™ treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over the counter, vitamins, herbal remedies, etc.).
• Do not receive any kind of immunization or vaccination without your doctor’s approval while taking Perjeta.
• Inform your health care professional if you are pregnant or may be pregnant prior to starting this “Perjeta” chemical treatment. Pregnancy pertuzumab precio category D (Perjeta™ may be hazardous to the fetus. Women who are pregnant Perjeta precio or become pregnant must advise of the potential hazard to the fetus.)
• For both men: Use contraceptives, and do not conceive a child (get pregnant) while taking Perjeta. Barrier methods of contraception, such as condoms, are recommended. Verify pregnancy status prior to treatment initiation. Effective contraception should be use during therapy and for 6 months after treatment.
• Do not breast feed while taking Perjeta.

Self-Care Tips:

• Drink at least two to three quarts of fluid every 24 hours, unless you are instructed otherwise.
• You may be at risk of infection so try to avoid crowds or people with colds, Perjeta 420 mg and report Perjeta 420 mg fiyat fever or any other signs of infection immediately to your health care provider.
• Wash your hands often.
• To help treat/prevent mouth sores, use a soft toothbrush, and rinse three times a day with 1 teaspoon of baking soda mixed with 8 ounces of water.
• Use an electric razor and a soft toothbrush to minimize bleeding.
• Avoid contact sports or activities that could cause injury.
• To reduce nausea, take anti-nausea medications as prescribed by your doctor, and eat small, frequent meals.
• Follow regimen of anti-diarrhea medication as prescribed by your health care professional.
• Eat foods that may help reduce diarrhea.
• Acetaminophen or ibuprofen may help relieve discomfort from fever, headache and/or generalized aches and pains. However, be sure to talk with your doctor before taking it.
• Avoid sun exposure. Wear SPF 15 (or higher) sun block and protective clothing.
• In general, drinking alcoholic beverages should keep to a minimum or avoided completely. You should discuss this with your doctor.
• Get plenty of rest.
• Maintain good nutrition.
• Remain active as you are able. Gentle exercise is encourage such as a daily walk.
• If you experience symptoms or side effects, be sure to discuss them with your health care team. They can Perjeta fiyat prescribe medications and/or offer other suggestions that are effective in managing such problems.

Monitoring and Testing:

• Lab work to check blood counts and liver/kidney functions will be check regularly by your health care professional while you are taking Perjeta, to monitor side effects and check your response to therapy.
• HER2 expression must be present for initiation of Perjeta.
• Negative pregnancy test prior to initiation.
• Cardiac studies to assess Left Ventricular Ejection Fracture (LVEF), may be ordered.

How Perjeta Works:

• Targeted therapy is the result of about 100 years of research dedicate to understanding the differences between cancer cells and normal cells. To date, cancer treatment has focused primarily on killing rapidly dividing cells because one feature of cancer cells is that they divide rapidly. Unfortunately, some of our normal cells divide rapidly too, causing multiple side effects.
• Targeted therapy is about identifying other features of cancer cells. Scientists look for specific differences in the cancer cells and the normal cells. This information is use to create a targeted therapy to attack the cancer cells without damaging the normal cells, thus leading to fewer side effects. Each type of targeted therapy works a little bit differently, but all interfere with the ability of the cancer cell to grow, divide, repair and/or communicate with other cells.
• There are different types of targeted therapies, defined in three broad categories. Some targeted therapies focus on the internal components and function of the cancer cell. The target therapies use small molecules that can get into the cell and disrupt the function of the cells, causing them to die.
• There are several types of targeted therapy that focus on the inner parts of the cells. Other targeted therapies target receptors that are on the outside of the cell. Therapies that target receptors are also know as monoclonal antibodies. Anti-angiogenesis inhibitors target the blood vessels that supply oxygen to the cells, ultimately causing the cells to starve.

More Info

• Perjeta has the component of an antibody type of targeted therapy. Antibodies are an integral part of the body’s immune system. Normally the body creates antibodies in response to an antigen (such as a protein or a germ) that has entered the body. The antibodies attach to the antigen in order to mark it for destruction by the immune system.
• To make anti-cancer antibodies in the laboratory, scientists analyze specific antigens on the surface of cancer cells (the targets). Then using animal and human proteins, they create a specific antibody that will attach to the target antigen on the cancer cells.
• When given to a patient, these antibodies will attach to matching antigens like a key fit a lock. Since antibodies target only specific cells, they may cause less toxicity to healthy cells. Monoclonal antibody therapy is usually only give for cancers in which antigens and the respective antibodies have identify already.

Dosage

• Recommend Doses And Schedules
  1. The initial dose of PERJETA is 840 mg by intravenous injection within 60 minutes, followed by 420 mg injection every three weeks for more than 30 to 60 minutes.
  2. When administered with PERJETA, the recommend dose of trastuzumab was 8 mg / kg by injection within 90 minutes, followed by 6 mg / kg by intravenous injection within 30 to 90 minutes every three weeks.
  3. PERJETA, trastuzumab and tachycardia should used sequentially. PERJETA and trastuzumab can give in any form. Taxane should give after PERJETA and trastuzumab. A screening time of 30 to 60 minutes is recommend after PERJETA infusion and before starting trastuzumab or any subsequent taxed infusions.
  4. In patients receiving an anthracycline-based regimen, Perjeta and trastuzumab should administered after completion of the Anthracycline treatment. Pertuzumab 420mg Injection price in good at Yourmedikart.

• Patient Selection

1. 1. Select patients based on HER2 protein overexpression or HER2 gene amplification in tumor samples [see INDICATIONS and Clinical Studies]. Evaluation of HER2 protein overexpression and HER2 gene amplification should performed using FDA-approved tests specific for breast cancer by laboratories with demonstrated competence. Information on FDA-approved tests for the detection of HER2
   2. Inadequate assay performance, including use of suboptimal fixed tissue, failure to use specific reagents, deviation from specific assay instructions, and failure to include appropriate controls for assay validation may result into unreliable results. Perjeta 420mg price in india minimal at Yourmedikart.

Therapeutic Indications

• Early breast cancer

Pertuzumab 420mg Injection is show for use in combination with Trastuzumab and Chemotherapy in:

1. 1.  The Neoadjuvant therapy of adult patients with HER2-positive, privately progress, inflammatory, or early stage breast cancer at high risk of recurrence.
   2.  The Adjuvant therapy of adult patients with HER2-positive early breast cancer at high risk of recurrence.

• Metastatic breast cancer

1. 1. Pertuzumab 420 mg injection with trastuzumab and docetaxel is recommend for adults with HER2-elevated untreated breast cancer those have not yet receive HER2 treatment or medication for metastatic disease.
   2. Perjeta 420mg price in India is bargain. Perjeta Injection price best in India used treat breast cancer. place with group of medication called monoclonal antibodies. Cost of Perjeta Steal in India

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How Perjeta works

Cancer cells grow out of control. Perjeta works on cancer cells by blocking chemical signaling that can lead to uncontrolled growth.

• Genetics is like a guidebook that tells every cell in our body how to grow, what kind of cell it will become, and how to behave. Genetics does this by telling the cell to produce a special protein that activates a specific function, such as growing cells, resting, or repairing it. Perjeta 420mg Pertuzumab  injection price in india check on Yourmedikart.
• Some cancer cells have abnormalities in the genes that tell them. For instance, How many cells there are and how fast they can grow. Sometimes cancer cells have many of these defective genes.
• in other words When there are too many of these genes, doctors talk about “extreme expression”. With some form of genetic hyperplasia, cancer cells will produce many proteins that regulate cell growth and division, causing cancer cells to grow and spread.

What to expect when taking Perjeta

When taking Perjeta (pertuzumab), patients can expect to receive it as part of a combination therapy, typically alongside trastuzumab and docetaxel, for the treatment of HER2-positive breast cancer. The treatment may be use in both the neoadjuvant (before surgery) and adjuvant (after surgery) settings. It’s important to monitor for possible side effects, including:

1. Infusion Reactions: Symptoms such as chills, fever, nausea, and headache may occur during or shortly after the infusion. Severe reactions can include difficulty breathing, chest pain, and anaphylaxis.
2. Cardiac Issues: Patients should monitor for heart problems, as pertuzumab can affect heart function, particularly left ventricular dysfunction.
3. Gastrointestinal Symptoms: Nausea, diarrhea, and vomiting are common. Pertuzumab 420mg Injection price is good online at Yourmedikart.
4. Skin Reactions: Rash and dry skin may occur.
5. Potential for Harm to Fetus: Women of childbearing age should use effective contraception during treatment and for some months after the final dose.

Regarding the price of Perjeta 420 mg in India, it varies depending on the supplier, location, and sometimes the healthcare setting. Since the cost can fluctuate and may be influenced by factors such as import policies and healthcare subsidies, it’s advisable to consult a local pharmacy or healthcare provider for the most accurate and current price information.

Warnings/Precautions:

• There is a risk of left ventricular dysfunction associate with the use of Pertuzumab. It is essential to monitor the left ventricular ejection fraction (LVEF) before starting treatment and periodically during treatment, for example, every 12 weeks for metastatic breast cancer (MBC) or early breast cancer (EBC), and once for neoadjuvant therapy. If there is a decrease in LVEF, discontinue Pertuzumab and trastuzumab (refer to all package inserts for detailed guidance).
• Patients with an LVEF level ≤ 50% prior to treatment, a history of congestive heart failure (CHF), a reduction in LVEF to < 50% during previous treatment with trastuzumab, uncontrolled hypertension, a recent myocardial infarction, significant cardiac arrhythmia requiring treatment, or a prior cumulative exposure to doxorubicin exceeding 360 mg/m^2 or its equivalent, have not been studied and may require additional monitoring or different management.
• Also, monitor for signs and symptoms of infusion reactions. If such reactions occur, delay or stop the treatment and address the issue as needed. In severe cases, consider permanently discontinuing treatment. There is also a risk of embryo-fetal toxicity. Women of childbearing potential should advise to use effective contraception during treatment and for 7 months following the last dose of Pertuzumab 420mg Injection.

Perjeta side effects

Perjeta is give with Herceptin and most importantly to aware that heart disease can lead to Herceptin side effects. Although studies have shown that adding. Similarly Perjeta Pertuzumab Injection in india to Herceptin does not increase the risk of heart disease. Moreover, your doctor may wish to test your heart function before and during treatment with Perjeta Pertuzumab Injection in india, Herceptin and chemotherapy. Perjeta 420mg Pertuzumab injection price in india. Pertuzumab 420mg Injection

The most common side effects of Perjeta are:

• Diarrhea
• Hair loss
• Thirdly Low white blood cell count (neutropenia)
• Crowd
• Weak
• Red rash
• Peripheral neuropathy for Instance, tingling. Perjeta 420mg Pertuzumab injection price in india minimal at Yourmedikart. Or burning of the hands and feet above all are common side effects.

When to contact your doctor or health care provider:

See your doctor right away, day or night, or go to the emergency room. If you experience any of the following symptoms:

FAQ

Is PERJETA 420 Mg a chemotherapy drug?

Perjeta (Pertuzumab) is consider cancer therapy and different from chemotherapy. Chemotherapy works by killing fast-growing cancer cells, but it also affects normal cells. Perjeta attacks certain proteins in breast cancer cells that cause rapid growth.

What is use of PERJETA 420 Mg?

PERJETA, together with Herceptin (trastuzumab) and docetaxel, is the first-line treatment for HER2+ breast cancer that has spread to other parts of the body (metastasis). So It will provided to you if you have not received anti-HER2 therapy or chemotherapy for metastatic breast cancer (first line).

What is PERJETA in cancer treatment?

Perjeta (chemical name: Pertuzumab) used in combination with another targeted therapy drug Herceptin (chemical name: trastuzumab) and a chemotherapy drug Texture (chemical name: docetaxel) HER2-positive metastatic breast cancer. After that He did not receive Herceptin or chemotherapy treatment.

How effective is PERJETA?

Disease-free survival rates in both groups were higher than expected: 94.1% of women in the Perjeta treatment group survived without cancer recurrence. 93.2% of women in the standard treatment group survived without cancer recurrence.

What does HER2-positive mean?

HER2 is a growth promoting protein outside of all breast cells. Breast cancer cells with higher levels of HER2 than normal are called HER2-positive. These cancers tend to grow and spread faster than other breast cancers. But are more likely to respond to drug treatments that target the HER2 protein.

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