Crinone Gel 8%

MERCK SERONO

PACKING: 1PFS

Description

Crinone 8 % Gel price in india has a similar action to the female hormone (chemical messenger) progesterone. It is used to treat various problems related to hormonal imbalance in the body, such as secondary amenorrhea (absence of three or more periods in a row) and infertility in women. Crinone 8 % Gel has some side effects like stomach pain and discomfort, drowsiness, breast pain and tenderness, vaginal irritation, etc. These side effects are mild and may subside by themselves. However, consult your doctor if they bother you for a longer time or worsen. Crinone 8 % Gel should be used as instructed by your doctor. Avoid using more than the recommended dose.

Use it every day at the same time for the ease of remembering. Your doctor may recommend that you continue using this medicine for a certain time after you get pregnant, as it will help to support your new pregnancy. Crinone 8 % Gel is not recommended for use if you are allergic to it. Inform your doctor if you have vaginal bleeding, kidney, liver, or heart problems, or any other medical conditions. Also, inform about all your current medications to avoid undesired effects. Crinone 8 % Gel is not indicated for use in children. This medicine may be used during pregnancy upon your doctor’s recommendation.

What is Crinone?

Crinone is medicine that contains the female hormone called progesterone.

What is Crinone used for?

Crinone 4% and Crinone 8% gel price in india are used to treat the absence of a menstrual period in a woman who has previously had a menstrual period. Progesterone is one of the hormones that allows women to have regular menstrual periods. When you do not produce enough progesterone, menstrual irregularities can occur. Crinone may be prescribed to increase your progesterone.
Crinone 8% is also used as part of a program for women who are undergoing fertility treatments to get pregnant. Progesterone is one of the hormones that helps to prepare the lining of your uterus so that it is ready to receive and nourish a fertilized egg and to continue a pregnancy. If you are undergoing ART treatment and your doctor has determined your body does not produce enough progesterone on its own, Crinone may be prescribed to increase your progesterone.
If pregnancy occurs, Crinone may be supplemented for 10 to 12 weeks until production of progesterone by the placenta is adequate.

Who should not use Crinone?

Do not start using Crinone if you:

Are allergic to progesterone, progesterone-like drugs, or any of the inactive ingredients in the gel (ask a pharmacist if you are not sure about the inactive ingredients in Crinone).
Have unusual vaginal bleeding which has not been evaluated by a doctor.
Have or have had a liver disease.
Have or have had cancer of the breast or genital organs.
Have had a miscarriage and your physician suspects some tissue is still in the uterus.
Have or have had blood clots in the legs, lungs, eyes, or elsewhere.

When not to use?

Allergy

Avoid using Crinone 8 % Gel if you are allergic to it. Seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulty, etc.

Abnormal vaginal bleeding

Avoid using Crinone 8 % Gel if you have abnormal vaginal bleeding that has not been diagnosed, as it may worsen your condition.

Breast cancer

Avoid using Crinone 8 % Gel if you have or are suspected of having breast cancer. Also, inform your doctor if you have a family history of breast cancer.

Miscarriage

Avoid using Crinone 8 % Gel if you have a missed abortion (when the foetus has died in the womb during pregnancy, however, the body has not yet recognize it and expelled from the body) or ectopic pregnancy (a fertilized egg grows outside a woman’s uterus).

Heart and blood vessel disorder

Avoid using Crinone 8 % gel price in india if you recently have had a stroke (brain damage due to interrupted blood supply to the brain), heart attack, or blood clot disorder, as it may worsen your condition.

Liver disease

Avoid using Crinone 8 % Gel price if you have liver problems due to the increase risk of liver injury.

Warnings

Warnings for special population

Pregnancy

Crinone 8 % Gel price is recommend for use during pregnancy only upon your doctor’s recommendation. Consult your doctor before using this medicine.

Breast-feeding

Crinone 8 % Gel is not recommend for use while breastfeeding unless necessary. Consult your doctor before using this medicine.

General warnings

Diabetes

Crinone 8 % Gel price may alter blood sugar levels. Hence, it should use with caution if you have diabetes (high blood sugar levels).

Other medicines

Crinone 8 % Gel gel price in india may interact with other medicines and cause undesired effects. Hence, inform your doctor about all your current medications before starting the treatment to avoid interaction. It is not recommend for use with other vaginal products, as it may alter the release and absorption of this medicine, thus reducing its effectiveness.

Fluid Retention

Oedema refers to the accumulation of fluid in the body tissues causing swelling, So especially in the legs and feet. Crinone 8 % Gel may cause fluid retention, particularly when used in high doses for a prolonged time. Hence, it should use with caution if you have heart or kidney problems, as it may further worsen your condition.

Side effects

Major & minor side effects for Crinone 8 % Gel

Vaginal discharge
Vaginal bleeding
Vaginal itching
Rash
Vaginal irritation
Nausea
Headache
Abdominal pain and discomfort
Drowsiness

What are the possible side effects of Crinone?

Serious side effects include:

Blood clots. Pregestational drug products may increase your chance of having blood clots in your blood vessels. Blood clots can cause:
- Blood vessel problems (thrombophlebitis)
- Stroke
- Loss of your arm or leg
- Blood clot in your lungs (pulmonary embolus)
- Heart Attack
- Death
Birth defects. Abdominal wall defect and cleft palate have report with Crinone use in early pregnancy. It is not know if these defects were cause by Crinone.

Call your healthcare provider right away if you get any of the following warning signs or any other unusual symptoms that concern you:

Pains in the calves or chest, a sudden shortness of breath or coughing blood indicating possible clots in the legs, heart, or lungs.
Severe headache or vomiting, dizziness, faintness, or changes in vision or speech, weakness or numbness of an arm or leg indicating possible clots in the brain or eye.

Contraindications

Crinone should not use in individuals with any of the following conditions:

Know sensitivity to Crinone (progesterone or any of the other ingredients)
Undiagnosed vaginal bleeding
Liver dysfunction or disease
Know or suspect malignancy of the breast or genital organs.
Missed abortion.
Active thrombophlebitis or thromboembolic disorders, or a history of hormone-associated thrombophlebitis or thromboembolic disorders

Precautions

General

The pretreatment physical examination should include special reference to breast and pelvic organs, as well as Papanicolaou smear.
In cases of breakthrough bleeding, as in all cases of irregular vaginal bleeding, nonfunctional causes should consider. In cases of undiagnose vaginal bleeding, adequate diagnostic measures should undertake.
Because progestogens may cause some degree of fluid retention, conditions which might be influence by this factor (e.g., epilepsy, migraine, asthma, cardiac or renal dysfunction) require careful observation.
The pathologist should advise of progesterone therapy when relevant specimens are submit.
Patients who have a history of psychic depression should carefully observe and the drug discontinue if the depression recurs to a serious degree.
A decrease in glucose tolerance has observe in a small percentage of patients on estrogen-progestin combination drugs. The mechanism of this decrease is not know. For this reason, diabetic patients should carefully observe while receiving progestin therapy.

Information for Patients

The product should not use concurrently with other local intravaginal therapy. If other local intravaginal therapy is to use concurrently, there should at least a 6-hour period before or after Crinone administration. Small, white globules may appear as a vaginal discharge possibly due to gel accumulation, even several days after usage.

Overdosage

Meanwhile There have been no reports of overdosage with Crinone gel price in india. In the case of overdosage, however, discontinue Crinone, treat the patient symptomatically, and institute supportive measures.

As with all prescription drugs, this medicine should keep out of the reach of children.

Crinone Dosage and Administration

Assisted Reproductive Technology

Firstly Crinone 8% gel price is administer vaginally at a dose of 90 mg once daily in women who require so progesterone supplementation. Secondly Crinone 8% is administer vaginally at a dose of 90 mg twice daily in women with partial or complete ovarian failure who require progesterone replacement. Because If pregnancy occurs, treatment may continue until placental autonomy is achieve, up to 10 to 12 weeks.

Secondary Amenorrhea

Crinone 4% is administer vaginally every other day up to a total of six doses. But For women who fail to respond, a trial of Crinone 8% every other day up to a total of six doses may be institute.

It is important to note that a dosage increase from the 4% gel can only be accomplish by using the 8% gel. Increasing the volume of gel administered does not increase the amount of progesterone absorb.

How is Crinone supply

Firstly Crinone gel price is available in the following strengths:

4% gel (45 mg) in a single use, disposable, white polypropylene vaginal applicator with a teal twist-off cap. Each applicator contains 1.3 g of gel and delivers 1.125 g of gel.

Thirdly NDC 0023-6150-04: 6 Single-use prefilled applicators.

8% gel (90 mg) in a single use, disposable, white polypropylene vaginal applicator with a teal twist-off cap. Each applicator contains 1.3 g of gel and delivers 1.125 g of gel.

NDC 0023-6151-08: 15 Single-use prefilled applicators.

Each applicator is wrap and seal in a foil overwrap.

FAQ

What is Crinone gel used for?

Crinone is used to give you extra progesterone in the treatment of infertility due to abnormal progesterone levels during your menstrual cycle or when you are using assisted reproductive technology. This is to help you conceive. You may be told to continue using Crinone to support your new pregnancy.

What are the side effects of Crinone?

Nausea, irritability, abdominal pain, constipation, diarrhea, nausea, breast swelling/pain, pain in the groin area, drowsiness, fatigue, decreased interest in sex, joint pain or headache may occur. If any of these side effects persist or worsen, tell your doctor or pharmacist right away.

Why do you need Crinone after IVF?

It is an important hormone to prepare the uterus (womb) for pregnancy and for continued support. Crinone is used to supplement or replace your natural progesterone in IVF programs.

Does Crinone stop your period?

Crinone (progesterone) contains progesterone, a natural sex hormone. It starts the menstrual cycle by helping to regulate the natural progesterone levels in the body.

How long do you use Crinone?

Your doctor may prescribe one applicator of CRINONE either daily or twice daily and will advise you when to start treatment. If pregnancy occurs treatment may continue for up to 12 weeks or as directed by your doctor. CRINONE should be used at the same time each day.

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