Calquence 100 Mg/60 Capsules

AstraZeneca

Generic Name : Acalabrutinib

Packing : 100 Mg/60 Capsules

Calquence

What is Calquence Used For and Calquence Cost?

Calquence is a prescription based medication used to treat adults with mantle cell lymphoma (MCL) who have received at least one earlier therapy for their cancer, or adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). Calquence cost is low in India. Acalabrutinib price and Acalabrutinib price in India is low at yourmedikart.store

Description

CALQUENCE (acalabrutinib) is a Bruton’s tyrosine kinase (BTK) inhibitor. The molecular formula of acaputinib is C26H23N7O2 and the molecular weight is 465.51. The chemical name is 4- {8-amino-3- [(2S) -1- (but-2 ynoyl) pyrrolidin-2-yl] imidazo[1,5-a] pyrazin-1-yl)}-N -(Pyridin-2-yl)benzamide. Acalabrutinib is a white to yellow powder with pH-dependent solubility. It is easily soluble in water when the pH value is lower than 3, and almost insoluble when the pH value is higher than 6. CALQUENCE capsules for oral administration contain 100 mg acalabrutinib and the following inactive ingredients: silicified microcrystalline cellulose, partially pregelatinized starch, magnesium stearate and sodium starch glycolate. The capsule shell contains gelatin, titanium dioxide, iron oxide yellow, FD&C Blue 2, and is printed with edible black ink.

How should I take Calquence?

Take Calquence with or without food.

Take Calquence exactly as your healthcare provider tells you to take it.

If you need to take certain other medicines called acid reducers (H2-receptor blockers), take Calquence 2 hours before the acid reducer medicine.

If you need to take an antacid medicine, take it either 2 hours before or 2 hours after you take Calquence.

Do not change your dose or stop taking Calquence unless your healthcare provider tells you to.

Take Calquence 2 times a day.

If you miss a dose of Calquence, take it as soon as you remember. If it is more than 3 hours past your usual dosing time, skip the missed dose and take your next dose of Calquence at your regularly scheduled time. Do not take an extra dose to make up for a missed dose.

Your healthcare provider may tell you to decrease your dose, temporarily stop, or completely stop taking, if you develop certain side effects.

Swallow capsules whole with a glass of water. Do not open, break, or chew capsules.

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Precautions

Before taking, tell your healthcare provider about all of your medical conditions if you:

  • have an infection.
  • have or had heart rhythm problems.
  • have or had liver problems, including hepatitis B virus (HBV) infection.
  • have had recent surgery or plan to have surgery. Your healthcare provider may stop Calquence for any planned medical, surgical, or dental procedure.
  • have bleeding problems
  • are breastfeeding or plan to breastfeed. It is not known if Calquence passes into your breast milk. Do not breastfeed during treatment and for at least 2 weeks after your final dose of Calquence.
  • are pregnant or plan to become pregnant. Calquence may harm your unborn baby and cause problems during childbirth (dystocia).
  • Females who are able to become pregnant should use effective birth control (contraception) during treatment and for at least 1 week after the last dose of Calquence.
  • If you are able to become pregnant, your healthcare provider may do a pregnancy test before you start treatment.

Calquence with certain other medications may affect and can cause side effects.

calquence

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What are the possible side effects of Calquence

  • Decrease in blood cell counts. Decreased blood counts (white blood cells, platelets, and red blood cells) are common, but can also be severe. Your healthcare provider should do blood tests to check your blood counts regularly during treatment.
  • Heart rhythm problems have happened in people. Tell your healthcare provider if you have any of the following signs or symptoms: fast or irregular heartbeat, dizziness, feeling faint, chest discomfort, or shortness of breath.
  • Bleeding problems (hemorrhage) can happen during treatment and can be serious and may lead to death. Your risk of bleeding may increase if you are also taking a blood thinner medicine. Tell your healthcare provider if you have any signs or symptoms of bleeding, including blood in your stools or black stools (looks like tar), pink or brown urine, unexpected bleeding or bleeding that is severe or you cannot control, vomit blood or vomit that looks like coffee grounds, cough up blood or blood clots, dizziness, weakness, confusion, changes in your speech, headache that lasts a long time, or bruising or red or purple skin marks.
  • Serious infections can happen during treatment and may lead to death. Your healthcare provider may prescribe certain medicines if you have an increased risk of getting infections. Tell your healthcare provider right away if you have any signs or symptoms of an infection, including fever, chills, or flu-like symptoms.

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Most Common Side Effects of

  • Joint pain
  • diarrhea
  • upper respiratory tract infection
  • bruising
  • headache
  • muscle pain

These are not all the possible side effects. Call your doctor for medical advice about side effects.

What other drugs will affect Calquence?

Many drugs can interact with acalabrutinib. Not all possible interactions are listed here. Tell your doctor about all the medicines you currently use and any medicines you start or stop using, especially: warfarin (Coumadin, Jantoven); antibiotics or antifungals; antivirals for hepatitis C or HIV/AIDS Drugs; heart drugs; or gastric acid reducers, such as omeprazole, lansoprazole, Nexium, Prevacid, Prilosec, Protonix, etc. This list is not complete and many other drugs may interact with acalabrutinib. This includes prescription and over-the-counter drugs, vitamins and herbal products. Provide a list of all your medicines to any healthcare provider who treats you.

Remember to keep this medicine and all other medicines out of the reach of children, never share your medicine with others, and only use Calquence for the prescribed indications.

Be sure to consult your healthcare provider to ensure that the information on this page is applicable to your personal situation.

Calquence Interactions

Avoid concomitant strong CYP3A inhibitors (eg, itraconazole); if short-term use (eg, anti-infectives for ≤7days), interrupt acalabrutinib therapy. Concomitant moderate CYP3A inhibitors, strong CYP3A inducers (eg, rifampin): see Adults. Increased risk of hemorrhage with concomitant antithrombotics; consider benefit/risk. Antagonized by gastric acid reducing agents (eg, PPI [avoid], H2-receptor antagonist, or antacid); if needed, consider ranitidine, famotidine, or calcium carbonate. Separate dosing by at least 2hrs with antacids. Take acalabrutinib 2hrs before H2-receptor antagonist use.

Dosage

Swallow whole with water. 100mg approx. every 12hrs until disease progression or unacceptable toxicity. In combination with obinutuzumab (CLL/SLL): initiate acalabrutinib at Cycle 1 of each 28-day cycle, then initiate obinutuzumab at Cycle 2 for a total of 6 cycles; give acalabrutinib prior to obinutuzumab if given on same day. Concomitant moderate CYP3A inhibitors: 100mg once daily. Concomitant strong CYP3A inducers: avoid; if needed, increase dose to 200mg every 12hrs. Dose modifications: see full labeling.

FAQ

What is Calquence used for?

Calquence is a prescription based medication used to treat adults with mantle cell lymphoma (MCL) who have received at least one earlier therapy for their cancer, or adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL).

Is Calquence a chemotherapy drug?

CALQUENCE is a specific alternative to traditional chemotherapy for CLL / SLL patients. It can be used for patients who have already received other treatments. CALQUENCE is a kinase inhibitor that can affect the growth of CLL / SLL cancer cells.

How long do you take Calquence?

CALQUENCE began to work soon after taking it to block Bruton's tyrosine kinase (BTK) and continued to work for the entire 12-hour period of administration.

How effective is Calquence?

In the final ASCEND analysis, it was estimated that 82% of patients with relapsed or refractory CLL treated with Calquence were still alive and progress-free at 18 months, while receiving rituximab with idelalisib or bendamole Among patients treated with stine combination therapy, this proportion was 48%.

Does Calquence cause weight gain?

After three years, 98% of patients still responded to Calquence, and 97% of patients had no progress. The treatment was generally well tolerated. The most common side effects include diarrhea, headache, upper respiratory tract infection, bruising, joint pain, weight gain, nausea and cough.

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