Albiomin 5% 250ML

BIOTEST

PACKING : 1POUCH

GENERIC NAME : HUMAN ALBUMIN

Indications and Usage

Conditions For Which Albiomin (Human) 5% Is Recommended:

Shock

The definitive treatment of major hemorrhage is the transfusion of red blood cells for restoring the normal oxygen transport capacity of the blood. Since, however, the life-threatening event in major hemorrhage is the loss of blood volume and not the erythrocyte deficit, the blood volume should, as an emergency measure, be supported by Albumin (Human) 5% or another rapidly acting plasma substitute if blood is not immediately available. This will restore cardiac output and abolish circulatory failure with tissue anoxia. In the presence of dehydration, electrolyte solutions such as Ringer’s lactate should be administered in conjunction with Albumin (Human).

Burns

Apart from damage to the respiratory tract, the development of burn shock is the most life-threatening event in the immediate care of the burned patient. An optimum regimen for the use of Albumin (Human), electrolytes, and fluid in the treatment of burns has not been established. Therapy during the first 24 hours after a severe burn is usually directed at the administration of large volumes of crystalloid solutions and lesser amounts of Albumin (Human) to maintain an adequate plasma volume. For continuation of therapy beyond 24 hours, larger amounts of Albumin (Human) and lesser amounts of crystalloid are generally used (12).

Conditions For Which Albiomin (Human) 5% May Be Useful:

Pancreatitis and Peritonitis

Albumin (Human) 5% may be useful in the early therapy of shock associated with acute hemorrhagic pancreatitis and peritonitis. It has been found that the correction of the blood volume deficit and adequate fluid therapy are mandatory in the acute stage of pancreatitis and peritonitis when there is loss of fluid into the peritoneal cavity or the retroperitoneal space (1).

Conditions For Which Albiomin (Human) 5% Is Usually Not Recommended:

Postoperative albumin loss

It is now recognized that intraoperative damage to capillary walls, e.g., by blunt handling and sharp dissection of tissue, leads to substantial postoperative losses of circulating albumin, over and above those due to bleeding. However, this internal redistribution rarely causes clinically significant hypovolemia or adversely affects wound healing, and treatment of this condition with Albumin (Human) 5% is usually not indicated.

Hypoproteinemia with an oncotic deficit

In subacute or chronic hypoproteinemia, efforts should always be made to determine the underlying cause and to improve circulating protein levels by dietary means. Most commonly, such states are due to protein-calorie malnutrition, defective absorption in gastrointestinal disorders, faulty albumin synthesis in chronic hepatic failure, increased protein catabolism after operation or in sepsis, and abnormal renal losses of albumin in chronic kidney disease. In all these situations, the circulating plasma volume is usually maintained by the renal retention of sodium and water, but this is associated with tissue edema due to the hypoalbuminemia and with an oncotic deficit. Though relief of the basic pathology is the definitive therapy for restoration of the plasma protein level, Albumin (Human) is effective in the rapid correction of an oncotic deficit occurring in the aforementioned acute complications of chronic hypoproteinemia. For this purpose, however, Albumin (Human) 25% is the preferable therapeutic agent, possibly in conjunction with a diuretic. It is emphasized that whereas Albumin (Human) may be needed to treat the acute complications of chronic hypoproteinemia, it is NOT indicated for treatment of the chronic disease itself.